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Update of inactivated equine influenza vaccine strain in Japan

Japan established a vaccine selection system, in which a committee evaluates veterinary influenza vaccines to determine if the vaccine should be updated. In 2013, it was concluded that the present equine influenza vaccine strains did not have to be updated, but clade 2 (Fc2) viruses of the Florida s...

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Autores principales: GAMOH, Koichiro, NAKAMURA, Shigeyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383192/
https://www.ncbi.nlm.nih.gov/pubmed/28163276
http://dx.doi.org/10.1292/jvms.16-0558
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author GAMOH, Koichiro
NAKAMURA, Shigeyuki
author_facet GAMOH, Koichiro
NAKAMURA, Shigeyuki
author_sort GAMOH, Koichiro
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description Japan established a vaccine selection system, in which a committee evaluates veterinary influenza vaccines to determine if the vaccine should be updated. In 2013, it was concluded that the present equine influenza vaccine strains did not have to be updated, but clade 2 (Fc2) viruses of the Florida sublineage should be included. We collected three Fc2 viruses as candidates and conducted comparative tests. Results indicated that A/equine/Carlow/2011 (H3N8) is not suitable, because of its unstable antigenic characteristics. A comparison between A/equine/Richmond/1/2007 (H3N8) (Richmond/07) and A/equine/Yokohama/aq13/2010 (H3N8) (Yokohama/10) in eggs showed that they shared equal growth properties. Immunogenicity test in mice showed that Yokohama/10 induced higher HI antibody titers than Richmond/07. Therefore, we concluded that Yokohama/10 was the most suitable strain.
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spelling pubmed-53831922017-04-11 Update of inactivated equine influenza vaccine strain in Japan GAMOH, Koichiro NAKAMURA, Shigeyuki J Vet Med Sci Virology Japan established a vaccine selection system, in which a committee evaluates veterinary influenza vaccines to determine if the vaccine should be updated. In 2013, it was concluded that the present equine influenza vaccine strains did not have to be updated, but clade 2 (Fc2) viruses of the Florida sublineage should be included. We collected three Fc2 viruses as candidates and conducted comparative tests. Results indicated that A/equine/Carlow/2011 (H3N8) is not suitable, because of its unstable antigenic characteristics. A comparison between A/equine/Richmond/1/2007 (H3N8) (Richmond/07) and A/equine/Yokohama/aq13/2010 (H3N8) (Yokohama/10) in eggs showed that they shared equal growth properties. Immunogenicity test in mice showed that Yokohama/10 induced higher HI antibody titers than Richmond/07. Therefore, we concluded that Yokohama/10 was the most suitable strain. The Japanese Society of Veterinary Science 2017-02-06 2017-03 /pmc/articles/PMC5383192/ /pubmed/28163276 http://dx.doi.org/10.1292/jvms.16-0558 Text en ©2017 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Virology
GAMOH, Koichiro
NAKAMURA, Shigeyuki
Update of inactivated equine influenza vaccine strain in Japan
title Update of inactivated equine influenza vaccine strain in Japan
title_full Update of inactivated equine influenza vaccine strain in Japan
title_fullStr Update of inactivated equine influenza vaccine strain in Japan
title_full_unstemmed Update of inactivated equine influenza vaccine strain in Japan
title_short Update of inactivated equine influenza vaccine strain in Japan
title_sort update of inactivated equine influenza vaccine strain in japan
topic Virology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383192/
https://www.ncbi.nlm.nih.gov/pubmed/28163276
http://dx.doi.org/10.1292/jvms.16-0558
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