A cutaneous mixed tumor in a dog

The atypical cutaneous tumor of a 9-year-old mixed breed female dog was examined. The tumor was well-demarcated and histologically composed of a trichoblastic area, tricholemmal area and apocrine glandular area. Neoplastic cells in trichoblastic area and tricholemmal area had PAS-positive granules i...

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Autores principales: WATANABE, Ken-ichi, CHAMBERS, James K., UCHIDA, Kazuyuki, NIBE, Kazumi, USHIO, Nanako, HORIUCHI, Noriyuki, KOBAYASHI, Yoshiyasu, NAKAYAMA, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2017
Materias:
Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383195/
https://www.ncbi.nlm.nih.gov/pubmed/28132963
http://dx.doi.org/10.1292/jvms.16-0610
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author WATANABE, Ken-ichi
CHAMBERS, James K.
UCHIDA, Kazuyuki
NIBE, Kazumi
USHIO, Nanako
HORIUCHI, Noriyuki
KOBAYASHI, Yoshiyasu
NAKAYAMA, Hiroyuki
author_facet WATANABE, Ken-ichi
CHAMBERS, James K.
UCHIDA, Kazuyuki
NIBE, Kazumi
USHIO, Nanako
HORIUCHI, Noriyuki
KOBAYASHI, Yoshiyasu
NAKAYAMA, Hiroyuki
author_sort WATANABE, Ken-ichi
collection PubMed
description The atypical cutaneous tumor of a 9-year-old mixed breed female dog was examined. The tumor was well-demarcated and histologically composed of a trichoblastic area, tricholemmal area and apocrine glandular area. Neoplastic cells in trichoblastic area and tricholemmal area had PAS-positive granules in the cytoplasm and were positive for pan-cytokeratin, cytokeratin 5/6, 14 and 19 and p63. Neoplastic cells in trichoblastic area were also positive for cytokeratin 15 and CD34. Neoplastic cells in apocrine glandular area were positive for pan-cytokeratin and cytokeratin 7, 18 and 19. Myoepithelial cell proliferation with osteocartilaginous metaplasia was observed in this area. Since neoplastic cells showed multiphenotypic differentiation for hair follicles and apocrine glands, the present case was diagnosed as a cutaneous mixed tumor.
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spelling pubmed-53831952017-04-11 A cutaneous mixed tumor in a dog WATANABE, Ken-ichi CHAMBERS, James K. UCHIDA, Kazuyuki NIBE, Kazumi USHIO, Nanako HORIUCHI, Noriyuki KOBAYASHI, Yoshiyasu NAKAYAMA, Hiroyuki J Vet Med Sci Pathology The atypical cutaneous tumor of a 9-year-old mixed breed female dog was examined. The tumor was well-demarcated and histologically composed of a trichoblastic area, tricholemmal area and apocrine glandular area. Neoplastic cells in trichoblastic area and tricholemmal area had PAS-positive granules in the cytoplasm and were positive for pan-cytokeratin, cytokeratin 5/6, 14 and 19 and p63. Neoplastic cells in trichoblastic area were also positive for cytokeratin 15 and CD34. Neoplastic cells in apocrine glandular area were positive for pan-cytokeratin and cytokeratin 7, 18 and 19. Myoepithelial cell proliferation with osteocartilaginous metaplasia was observed in this area. Since neoplastic cells showed multiphenotypic differentiation for hair follicles and apocrine glands, the present case was diagnosed as a cutaneous mixed tumor. The Japanese Society of Veterinary Science 2017-01-28 2017-03 /pmc/articles/PMC5383195/ /pubmed/28132963 http://dx.doi.org/10.1292/jvms.16-0610 Text en ©2017 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Pathology
WATANABE, Ken-ichi
CHAMBERS, James K.
UCHIDA, Kazuyuki
NIBE, Kazumi
USHIO, Nanako
HORIUCHI, Noriyuki
KOBAYASHI, Yoshiyasu
NAKAYAMA, Hiroyuki
A cutaneous mixed tumor in a dog
title A cutaneous mixed tumor in a dog
title_full A cutaneous mixed tumor in a dog
title_fullStr A cutaneous mixed tumor in a dog
title_full_unstemmed A cutaneous mixed tumor in a dog
title_short A cutaneous mixed tumor in a dog
title_sort cutaneous mixed tumor in a dog
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383195/
https://www.ncbi.nlm.nih.gov/pubmed/28132963
http://dx.doi.org/10.1292/jvms.16-0610
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