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Production of putative enhanced oral cholera vaccine strains that express toxin-coregulated pilus
The use of whole cell killed (WCK) oral cholera vaccines is an important strategy for cholera prevention in endemic areas. To overcome current vaccine limitations, we engineered strains of V. cholerae to be non-toxigenic and to express the protective protein colonization factor, toxin-coregulated pi...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383245/ https://www.ncbi.nlm.nih.gov/pubmed/28384206 http://dx.doi.org/10.1371/journal.pone.0175170 |