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Localization of AML-related nucleophosmin mutant depends on its subtype and is highly affected by its interaction with wild-type NPM

Mutations of the gene for nucleophosmin (NPM1) are the most frequent genetic aberration in patients with acute myeloid leukemia (AML). The mechanism of leukemic transformation in this leukemia subtype is not fully understood, but aberrant cytoplasmic localization of mutated NPM (NPMmut) is widely co...

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Detalles Bibliográficos
Autores principales:	Brodská, Barbora, Kráčmarová, Markéta, Holoubek, Aleš, Kuželová, Kateřina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383266/ https://www.ncbi.nlm.nih.gov/pubmed/28384310 http://dx.doi.org/10.1371/journal.pone.0175175

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