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Different reprogramming propensities in plants and mammals: Are small variations in the core network wirings responsible?

Although the plant and animal kingdoms were separated more than 1,6 billion years ago, multicellular development is for both guided by similar transcriptional, epigenetic and posttranscriptional machinery. One may ask to what extent there are similarities and differences in the gene regulation circu...

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Autores principales: Olariu, Victor, Nilsson, Julia, Jönsson, Henrik, Peterson, Carsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383272/
https://www.ncbi.nlm.nih.gov/pubmed/28384293
http://dx.doi.org/10.1371/journal.pone.0175251
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author Olariu, Victor
Nilsson, Julia
Jönsson, Henrik
Peterson, Carsten
author_facet Olariu, Victor
Nilsson, Julia
Jönsson, Henrik
Peterson, Carsten
author_sort Olariu, Victor
collection PubMed
description Although the plant and animal kingdoms were separated more than 1,6 billion years ago, multicellular development is for both guided by similar transcriptional, epigenetic and posttranscriptional machinery. One may ask to what extent there are similarities and differences in the gene regulation circuits and their dynamics when it comes to important processes like stem cell regulation. The key players in mouse embryonic stem cells governing pluripotency versus differentiation are Oct4, Sox2 and Nanog. Correspondingly, the WUSCHEL and CLAVATA3 genes represent a core in the Shoot Apical Meristem regulation for plants. In addition, both systems have designated genes that turn on differentiation. There is very little molecular homology between mammals and plants for these core regulators. Here, we focus on functional homologies by performing a comparison between the circuitry connecting these players in plants and animals and find striking similarities, suggesting that comparable regulatory logics have been evolved for stem cell regulation in both kingdoms. From in silico simulations we find similar differentiation dynamics. Further when in the differentiated state, the cells are capable of regaining the stem cell state. We find that the propensity for this is higher for plants as compared to mammalians. Our investigation suggests that, despite similarity in core regulatory networks, the dynamics of these can contribute to plant cells being more plastic than mammalian cells, i.e. capable to reorganize from single differentiated cells to whole plants—reprogramming. The presence of an incoherent feed-forward loop in the mammalian core circuitry could be the origin of the different reprogramming behaviour.
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spelling pubmed-53832722017-05-03 Different reprogramming propensities in plants and mammals: Are small variations in the core network wirings responsible? Olariu, Victor Nilsson, Julia Jönsson, Henrik Peterson, Carsten PLoS One Research Article Although the plant and animal kingdoms were separated more than 1,6 billion years ago, multicellular development is for both guided by similar transcriptional, epigenetic and posttranscriptional machinery. One may ask to what extent there are similarities and differences in the gene regulation circuits and their dynamics when it comes to important processes like stem cell regulation. The key players in mouse embryonic stem cells governing pluripotency versus differentiation are Oct4, Sox2 and Nanog. Correspondingly, the WUSCHEL and CLAVATA3 genes represent a core in the Shoot Apical Meristem regulation for plants. In addition, both systems have designated genes that turn on differentiation. There is very little molecular homology between mammals and plants for these core regulators. Here, we focus on functional homologies by performing a comparison between the circuitry connecting these players in plants and animals and find striking similarities, suggesting that comparable regulatory logics have been evolved for stem cell regulation in both kingdoms. From in silico simulations we find similar differentiation dynamics. Further when in the differentiated state, the cells are capable of regaining the stem cell state. We find that the propensity for this is higher for plants as compared to mammalians. Our investigation suggests that, despite similarity in core regulatory networks, the dynamics of these can contribute to plant cells being more plastic than mammalian cells, i.e. capable to reorganize from single differentiated cells to whole plants—reprogramming. The presence of an incoherent feed-forward loop in the mammalian core circuitry could be the origin of the different reprogramming behaviour. Public Library of Science 2017-04-06 /pmc/articles/PMC5383272/ /pubmed/28384293 http://dx.doi.org/10.1371/journal.pone.0175251 Text en © 2017 Olariu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Olariu, Victor
Nilsson, Julia
Jönsson, Henrik
Peterson, Carsten
Different reprogramming propensities in plants and mammals: Are small variations in the core network wirings responsible?
title Different reprogramming propensities in plants and mammals: Are small variations in the core network wirings responsible?
title_full Different reprogramming propensities in plants and mammals: Are small variations in the core network wirings responsible?
title_fullStr Different reprogramming propensities in plants and mammals: Are small variations in the core network wirings responsible?
title_full_unstemmed Different reprogramming propensities in plants and mammals: Are small variations in the core network wirings responsible?
title_short Different reprogramming propensities in plants and mammals: Are small variations in the core network wirings responsible?
title_sort different reprogramming propensities in plants and mammals: are small variations in the core network wirings responsible?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383272/
https://www.ncbi.nlm.nih.gov/pubmed/28384293
http://dx.doi.org/10.1371/journal.pone.0175251
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