Addressing a weakness of anticancer therapy with mitosis inhibitors: Mitotic slippage

Mitosis inhibitors, which include antimicrotubule drugs, are chemotherapy agents that induce the arrest and apoptosis of mitotic cells. Mitotic slippage, in which mitotically arrested cells exit mitosis, limits the effectiveness of mitosis inhibitors. We have discovered that the CRL2(ZYG11A/B) ubiqu...

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Detalles Bibliográficos
Autores principales: Balachandran, Riju S., Kipreos, Edward T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383364/
https://www.ncbi.nlm.nih.gov/pubmed/28401182
http://dx.doi.org/10.1080/23723556.2016.1277293
Descripción
Sumario:Mitosis inhibitors, which include antimicrotubule drugs, are chemotherapy agents that induce the arrest and apoptosis of mitotic cells. Mitotic slippage, in which mitotically arrested cells exit mitosis, limits the effectiveness of mitosis inhibitors. We have discovered that the CRL2(ZYG11A/B) ubiquitin ligase promotes mitotic slippage. The combination of antimicrotubule drugs and a CRL2(ZYG11A/B) inhibitor prevents mitotic slippage to increase antimitotic efficacy.

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