KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number

We have recently identified the first human lysine (K) acetyltransferase 2A and 2B (called KAT2A/2B; known also as GCN5/PCAF, respectively)-dependent acetylome and revealed a mechanism by which KAT2A/2B-mediated acetylation of serine/threonine polo-like kinase 4 (PLK4) maintains correct centrosome n...

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Detalles Bibliográficos
Autores principales: Fournier, Marjorie, Tora, László
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383365/
https://www.ncbi.nlm.nih.gov/pubmed/28401181
http://dx.doi.org/10.1080/23723556.2016.1270391
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author Fournier, Marjorie
Tora, László
author_facet Fournier, Marjorie
Tora, László
author_sort Fournier, Marjorie
collection PubMed
description We have recently identified the first human lysine (K) acetyltransferase 2A and 2B (called KAT2A/2B; known also as GCN5/PCAF, respectively)-dependent acetylome and revealed a mechanism by which KAT2A/2B-mediated acetylation of serine/threonine polo-like kinase 4 (PLK4) maintains correct centrosome number in human cells, therefore contributing to the maintenance of genome stability.(1)
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spelling pubmed-53833652017-12-16 KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number Fournier, Marjorie Tora, László Mol Cell Oncol Author's View We have recently identified the first human lysine (K) acetyltransferase 2A and 2B (called KAT2A/2B; known also as GCN5/PCAF, respectively)-dependent acetylome and revealed a mechanism by which KAT2A/2B-mediated acetylation of serine/threonine polo-like kinase 4 (PLK4) maintains correct centrosome number in human cells, therefore contributing to the maintenance of genome stability.(1) Taylor & Francis 2016-12-16 /pmc/articles/PMC5383365/ /pubmed/28401181 http://dx.doi.org/10.1080/23723556.2016.1270391 Text en © 2017 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's View
Fournier, Marjorie
Tora, László
KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number
title KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number
title_full KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number
title_fullStr KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number
title_full_unstemmed KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number
title_short KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number
title_sort kat2-mediated plk4 acetylation contributes to genomic stability by preserving centrosome number
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383365/
https://www.ncbi.nlm.nih.gov/pubmed/28401181
http://dx.doi.org/10.1080/23723556.2016.1270391
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AT toralaszlo kat2mediatedplk4acetylationcontributestogenomicstabilitybypreservingcentrosomenumber

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