A pre-neoplastic epigenetic field defect in HCV-infected liver at transcription factor binding sites and polycomb targets

The predisposition of patients with Hepatitis C virus (HCV) infection to hepatocellular carcinoma (HCC) involves components of viral infection, inflammation and time. The development of multifocal, genetically distinct tumours is suggestive of a field defect affecting the entire liver. The molecular...

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Detalles Bibliográficos
Autores principales: Wijetunga, N A, Pascual, M, Tozour, J, Delahaye, F, Alani, M, Adeyeye, M, Wolkoff, A W, Verma, A, Greally, J M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Oncogenomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383522/
https://www.ncbi.nlm.nih.gov/pubmed/27721404
http://dx.doi.org/10.1038/onc.2016.340

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