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Risk Factors for Stroke among Young-Old and Old-Old Community-Dwelling Adults in Japan: The Ohasama Study

Aim: Few studies have addressed stroke risk factors in older populations, particularly among the old-old. We examined differences in traditional risk factors for stroke among the old-old compared with the young-old in community-dwelling Japanese adults. Methods: We followed 2,065 residents aged ≥ 60...

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Autores principales: Murakami, Keiko, Asayama, Kei, Satoh, Michihiro, Inoue, Ryusuke, Tsubota-Utsugi, Megumi, Hosaka, Miki, Matsuda, Ayako, Nomura, Kyoko, Murakami, Takahisa, Kikuya, Masahiro, Metoki, Hirohito, Imai, Yutaka, Ohkubo, Takayoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Atherosclerosis Society 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383545/
https://www.ncbi.nlm.nih.gov/pubmed/27487854
http://dx.doi.org/10.5551/jat.35766
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author Murakami, Keiko
Asayama, Kei
Satoh, Michihiro
Inoue, Ryusuke
Tsubota-Utsugi, Megumi
Hosaka, Miki
Matsuda, Ayako
Nomura, Kyoko
Murakami, Takahisa
Kikuya, Masahiro
Metoki, Hirohito
Imai, Yutaka
Ohkubo, Takayoshi
author_facet Murakami, Keiko
Asayama, Kei
Satoh, Michihiro
Inoue, Ryusuke
Tsubota-Utsugi, Megumi
Hosaka, Miki
Matsuda, Ayako
Nomura, Kyoko
Murakami, Takahisa
Kikuya, Masahiro
Metoki, Hirohito
Imai, Yutaka
Ohkubo, Takayoshi
author_sort Murakami, Keiko
collection PubMed
description Aim: Few studies have addressed stroke risk factors in older populations, particularly among the old-old. We examined differences in traditional risk factors for stroke among the old-old compared with the young-old in community-dwelling Japanese adults. Methods: We followed 2,065 residents aged ≥ 60 years who had no history of stroke. Traditional risk factors for stroke were obtained from a self-administered questionnaire at baseline. We classified participants into two age categories, 60–74 years (n = 1,502) and ≥ 75 years (n = 563), and assessed whether traditional risk factors were differentially associated with stroke incidence according to age category. Hazard ratios were calculated by the Cox proportional hazards model, adjusting for confounding factors and competing risk of death. Results: During a median follow-up of 12.8 and 7.9 years, 163 and 111 participants aged 60–74 and ≥ 75 years, respectively, developed a first stroke. Hypertension was consistently associated with increased risk of stroke, regardless of age category. Diabetes mellitus was associated with increased risk of stroke in those aged 60–74 years (hazard ratio, 1.50; 95% confidence interval, 1.00–2.25), but not in those aged ≥ 75 years (hazard ratio, 0.65; 95% confidence interval, 0.33–1.29), with significant interaction by age (P = 0.035). No traditional risk factor other than hypertension was associated with stroke among those aged ≥ 75 years. Conclusion: Those with hypertension had significantly higher stroke risk among old people, while diabetes mellitus was differentially associated with stroke according to age category. Our findings indicate the importance of different prevention strategies for stroke incidence according to age category.
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spelling pubmed-53835452017-04-21 Risk Factors for Stroke among Young-Old and Old-Old Community-Dwelling Adults in Japan: The Ohasama Study Murakami, Keiko Asayama, Kei Satoh, Michihiro Inoue, Ryusuke Tsubota-Utsugi, Megumi Hosaka, Miki Matsuda, Ayako Nomura, Kyoko Murakami, Takahisa Kikuya, Masahiro Metoki, Hirohito Imai, Yutaka Ohkubo, Takayoshi J Atheroscler Thromb Original Article Aim: Few studies have addressed stroke risk factors in older populations, particularly among the old-old. We examined differences in traditional risk factors for stroke among the old-old compared with the young-old in community-dwelling Japanese adults. Methods: We followed 2,065 residents aged ≥ 60 years who had no history of stroke. Traditional risk factors for stroke were obtained from a self-administered questionnaire at baseline. We classified participants into two age categories, 60–74 years (n = 1,502) and ≥ 75 years (n = 563), and assessed whether traditional risk factors were differentially associated with stroke incidence according to age category. Hazard ratios were calculated by the Cox proportional hazards model, adjusting for confounding factors and competing risk of death. Results: During a median follow-up of 12.8 and 7.9 years, 163 and 111 participants aged 60–74 and ≥ 75 years, respectively, developed a first stroke. Hypertension was consistently associated with increased risk of stroke, regardless of age category. Diabetes mellitus was associated with increased risk of stroke in those aged 60–74 years (hazard ratio, 1.50; 95% confidence interval, 1.00–2.25), but not in those aged ≥ 75 years (hazard ratio, 0.65; 95% confidence interval, 0.33–1.29), with significant interaction by age (P = 0.035). No traditional risk factor other than hypertension was associated with stroke among those aged ≥ 75 years. Conclusion: Those with hypertension had significantly higher stroke risk among old people, while diabetes mellitus was differentially associated with stroke according to age category. Our findings indicate the importance of different prevention strategies for stroke incidence according to age category. Japan Atherosclerosis Society 2017-03-01 /pmc/articles/PMC5383545/ /pubmed/27487854 http://dx.doi.org/10.5551/jat.35766 Text en 2017 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Original Article
Murakami, Keiko
Asayama, Kei
Satoh, Michihiro
Inoue, Ryusuke
Tsubota-Utsugi, Megumi
Hosaka, Miki
Matsuda, Ayako
Nomura, Kyoko
Murakami, Takahisa
Kikuya, Masahiro
Metoki, Hirohito
Imai, Yutaka
Ohkubo, Takayoshi
Risk Factors for Stroke among Young-Old and Old-Old Community-Dwelling Adults in Japan: The Ohasama Study
title Risk Factors for Stroke among Young-Old and Old-Old Community-Dwelling Adults in Japan: The Ohasama Study
title_full Risk Factors for Stroke among Young-Old and Old-Old Community-Dwelling Adults in Japan: The Ohasama Study
title_fullStr Risk Factors for Stroke among Young-Old and Old-Old Community-Dwelling Adults in Japan: The Ohasama Study
title_full_unstemmed Risk Factors for Stroke among Young-Old and Old-Old Community-Dwelling Adults in Japan: The Ohasama Study
title_short Risk Factors for Stroke among Young-Old and Old-Old Community-Dwelling Adults in Japan: The Ohasama Study
title_sort risk factors for stroke among young-old and old-old community-dwelling adults in japan: the ohasama study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383545/
https://www.ncbi.nlm.nih.gov/pubmed/27487854
http://dx.doi.org/10.5551/jat.35766
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