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The Cell Biology of the Trichosporon-Host Interaction

Fungi of the genus Trichosporon are increasingly recognized as causative agents of superficial and invasive fungal disease in humans. Although most species are considered commensals of the human skin and gastrointestinal tract, these basidiomycetes are an increasing cause of fungal disease among imm...

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Autores principales: Duarte-Oliveira, Cláudio, Rodrigues, Fernando, Gonçalves, Samuel M., Goldman, Gustavo H., Carvalho, Agostinho, Cunha, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383668/
https://www.ncbi.nlm.nih.gov/pubmed/28439501
http://dx.doi.org/10.3389/fcimb.2017.00118
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author Duarte-Oliveira, Cláudio
Rodrigues, Fernando
Gonçalves, Samuel M.
Goldman, Gustavo H.
Carvalho, Agostinho
Cunha, Cristina
author_facet Duarte-Oliveira, Cláudio
Rodrigues, Fernando
Gonçalves, Samuel M.
Goldman, Gustavo H.
Carvalho, Agostinho
Cunha, Cristina
author_sort Duarte-Oliveira, Cláudio
collection PubMed
description Fungi of the genus Trichosporon are increasingly recognized as causative agents of superficial and invasive fungal disease in humans. Although most species are considered commensals of the human skin and gastrointestinal tract, these basidiomycetes are an increasing cause of fungal disease among immunocompromised hosts, such as hematological patients and solid organ transplant recipients. The initiation of commensal or pathogenic programs by Trichosporon spp. involves the adaptation to the host microenvironment and its immune system. However, the exact virulence factors activated upon the transition to a pathogenic lifestyle, including the intricate biology of the cell wall, and how these interact with and subvert the host immune responses remain largely unknown. Here, we revisit our current understanding of the virulence attributes of Trichosporon spp., particularly T. asahii, and their interaction with the host immune system, and accommodate this knowledge within novel perspectives on fungal diagnostics and therapeutics.
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spelling pubmed-53836682017-04-24 The Cell Biology of the Trichosporon-Host Interaction Duarte-Oliveira, Cláudio Rodrigues, Fernando Gonçalves, Samuel M. Goldman, Gustavo H. Carvalho, Agostinho Cunha, Cristina Front Cell Infect Microbiol Microbiology Fungi of the genus Trichosporon are increasingly recognized as causative agents of superficial and invasive fungal disease in humans. Although most species are considered commensals of the human skin and gastrointestinal tract, these basidiomycetes are an increasing cause of fungal disease among immunocompromised hosts, such as hematological patients and solid organ transplant recipients. The initiation of commensal or pathogenic programs by Trichosporon spp. involves the adaptation to the host microenvironment and its immune system. However, the exact virulence factors activated upon the transition to a pathogenic lifestyle, including the intricate biology of the cell wall, and how these interact with and subvert the host immune responses remain largely unknown. Here, we revisit our current understanding of the virulence attributes of Trichosporon spp., particularly T. asahii, and their interaction with the host immune system, and accommodate this knowledge within novel perspectives on fungal diagnostics and therapeutics. Frontiers Media S.A. 2017-04-07 /pmc/articles/PMC5383668/ /pubmed/28439501 http://dx.doi.org/10.3389/fcimb.2017.00118 Text en Copyright © 2017 Duarte-Oliveira, Rodrigues, Gonçalves, Goldman, Carvalho and Cunha. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Duarte-Oliveira, Cláudio
Rodrigues, Fernando
Gonçalves, Samuel M.
Goldman, Gustavo H.
Carvalho, Agostinho
Cunha, Cristina
The Cell Biology of the Trichosporon-Host Interaction
title The Cell Biology of the Trichosporon-Host Interaction
title_full The Cell Biology of the Trichosporon-Host Interaction
title_fullStr The Cell Biology of the Trichosporon-Host Interaction
title_full_unstemmed The Cell Biology of the Trichosporon-Host Interaction
title_short The Cell Biology of the Trichosporon-Host Interaction
title_sort cell biology of the trichosporon-host interaction
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383668/
https://www.ncbi.nlm.nih.gov/pubmed/28439501
http://dx.doi.org/10.3389/fcimb.2017.00118
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