A role for the spindle assembly checkpoint in the DNA damage response

Spontaneous DNA damage poses a continuous threat to genomic integrity. If unchecked, genotoxic insults result in genomic instability, a hallmark of cancer cells. In eukaryotic cells a DNA Damage Response (DDR) detects and responds to genotoxic stress, acting as an anti-cancer barrier in humans. Amon...

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Detalles Bibliográficos
Autores principales: Palou, Roger, Palou, Gloria, Quintana, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383677/
https://www.ncbi.nlm.nih.gov/pubmed/27488803
http://dx.doi.org/10.1007/s00294-016-0634-y

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