A conserved role of the RSC chromatin remodeler in the establishment of nucleosome-depleted regions

The occupancy of nucleosomes governs access to the eukaryotic genomes and results from a combination of biophysical features and the effect of ATP-dependent remodelling complexes. Most promoter regions show a conserved pattern characterized by a nucleosome-depleted region (NDR) flanked by nucleosoma...

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Autores principales: Yague-Sanz, Carlo, Vázquez, Enrique, Sánchez, Mar, Antequera, Francisco, Hermand, Damien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383693/
https://www.ncbi.nlm.nih.gov/pubmed/27558480
http://dx.doi.org/10.1007/s00294-016-0642-y
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author Yague-Sanz, Carlo
Vázquez, Enrique
Sánchez, Mar
Antequera, Francisco
Hermand, Damien
author_facet Yague-Sanz, Carlo
Vázquez, Enrique
Sánchez, Mar
Antequera, Francisco
Hermand, Damien
author_sort Yague-Sanz, Carlo
collection PubMed
description The occupancy of nucleosomes governs access to the eukaryotic genomes and results from a combination of biophysical features and the effect of ATP-dependent remodelling complexes. Most promoter regions show a conserved pattern characterized by a nucleosome-depleted region (NDR) flanked by nucleosomal arrays. The conserved RSC remodeler was reported to be critical to establish NDR in vivo in budding yeast but other evidences suggested that this activity may not be conserved in fission yeast. By reanalysing and expanding previously published data, we propose that NDR formation requires, at least partially, RSC in both yeast species. We also discuss the most prominent biological role of RSC and the possibility that non-essential subunits do not define alternate versions of the complex.
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spelling pubmed-53836932017-04-20 A conserved role of the RSC chromatin remodeler in the establishment of nucleosome-depleted regions Yague-Sanz, Carlo Vázquez, Enrique Sánchez, Mar Antequera, Francisco Hermand, Damien Curr Genet Review The occupancy of nucleosomes governs access to the eukaryotic genomes and results from a combination of biophysical features and the effect of ATP-dependent remodelling complexes. Most promoter regions show a conserved pattern characterized by a nucleosome-depleted region (NDR) flanked by nucleosomal arrays. The conserved RSC remodeler was reported to be critical to establish NDR in vivo in budding yeast but other evidences suggested that this activity may not be conserved in fission yeast. By reanalysing and expanding previously published data, we propose that NDR formation requires, at least partially, RSC in both yeast species. We also discuss the most prominent biological role of RSC and the possibility that non-essential subunits do not define alternate versions of the complex. Springer Berlin Heidelberg 2016-08-24 2017 /pmc/articles/PMC5383693/ /pubmed/27558480 http://dx.doi.org/10.1007/s00294-016-0642-y Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Yague-Sanz, Carlo
Vázquez, Enrique
Sánchez, Mar
Antequera, Francisco
Hermand, Damien
A conserved role of the RSC chromatin remodeler in the establishment of nucleosome-depleted regions
title A conserved role of the RSC chromatin remodeler in the establishment of nucleosome-depleted regions
title_full A conserved role of the RSC chromatin remodeler in the establishment of nucleosome-depleted regions
title_fullStr A conserved role of the RSC chromatin remodeler in the establishment of nucleosome-depleted regions
title_full_unstemmed A conserved role of the RSC chromatin remodeler in the establishment of nucleosome-depleted regions
title_short A conserved role of the RSC chromatin remodeler in the establishment of nucleosome-depleted regions
title_sort conserved role of the rsc chromatin remodeler in the establishment of nucleosome-depleted regions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383693/
https://www.ncbi.nlm.nih.gov/pubmed/27558480
http://dx.doi.org/10.1007/s00294-016-0642-y
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