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The Emerging Role of Epigenetics in Autoimmune Thyroid Diseases
Autoimmune thyroid diseases (AITD) are a group of both B cell- and T cell-mediated organ-specific autoimmune diseases. Graves’ disease and Hashimoto thyroiditis are the two main clinical presentations of AITD. Both genetic and environmental factors have important roles in the development of AITD. Ep...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383710/ https://www.ncbi.nlm.nih.gov/pubmed/28439272 http://dx.doi.org/10.3389/fimmu.2017.00396 |
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author | Wang, Bin Shao, Xiaoqing Song, Ronghua Xu, Donghua Zhang, Jin-an |
author_facet | Wang, Bin Shao, Xiaoqing Song, Ronghua Xu, Donghua Zhang, Jin-an |
author_sort | Wang, Bin |
collection | PubMed |
description | Autoimmune thyroid diseases (AITD) are a group of both B cell- and T cell-mediated organ-specific autoimmune diseases. Graves’ disease and Hashimoto thyroiditis are the two main clinical presentations of AITD. Both genetic and environmental factors have important roles in the development of AITD. Epigenetics have been considered to exert key roles in integrating those genetic and environmental factors, and epigenetic modifications caused by environmental factors may drive genetically susceptibility individuals to develop AITD. Recent studies on the epigenetics of AITD have provided some novel insights into the pathogenesis of AITD. The aim of this review is to provide an overview of recent advances in the epigenetic mechanisms of AITD, such as DNA methylation, histone modifications, and non-coding RNAs. This review highlights the key roles of epigenetics in the pathogenesis of AITD and potential clinical utility. However, the epigenetic roles in AITD are still not fully elucidated, and more researches are needed to provide further deeper insights into the roles of epigenetics in AITD and to uncover new therapeutic targets. Although there are many studies assessing the epigenetic modifications in AITD patients, the clinical utility of epigenetics in AITD remains poorly defined. More studies are needed to identify the underlying epigenetic modifications that can contribute to accurate diagnosis of AITD, adequate choice of treatment approach, and precise prediction of treatment outcomes. |
format | Online Article Text |
id | pubmed-5383710 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-53837102017-04-24 The Emerging Role of Epigenetics in Autoimmune Thyroid Diseases Wang, Bin Shao, Xiaoqing Song, Ronghua Xu, Donghua Zhang, Jin-an Front Immunol Immunology Autoimmune thyroid diseases (AITD) are a group of both B cell- and T cell-mediated organ-specific autoimmune diseases. Graves’ disease and Hashimoto thyroiditis are the two main clinical presentations of AITD. Both genetic and environmental factors have important roles in the development of AITD. Epigenetics have been considered to exert key roles in integrating those genetic and environmental factors, and epigenetic modifications caused by environmental factors may drive genetically susceptibility individuals to develop AITD. Recent studies on the epigenetics of AITD have provided some novel insights into the pathogenesis of AITD. The aim of this review is to provide an overview of recent advances in the epigenetic mechanisms of AITD, such as DNA methylation, histone modifications, and non-coding RNAs. This review highlights the key roles of epigenetics in the pathogenesis of AITD and potential clinical utility. However, the epigenetic roles in AITD are still not fully elucidated, and more researches are needed to provide further deeper insights into the roles of epigenetics in AITD and to uncover new therapeutic targets. Although there are many studies assessing the epigenetic modifications in AITD patients, the clinical utility of epigenetics in AITD remains poorly defined. More studies are needed to identify the underlying epigenetic modifications that can contribute to accurate diagnosis of AITD, adequate choice of treatment approach, and precise prediction of treatment outcomes. Frontiers Media S.A. 2017-04-07 /pmc/articles/PMC5383710/ /pubmed/28439272 http://dx.doi.org/10.3389/fimmu.2017.00396 Text en Copyright © 2017 Wang, Shao, Song, Xu and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Wang, Bin Shao, Xiaoqing Song, Ronghua Xu, Donghua Zhang, Jin-an The Emerging Role of Epigenetics in Autoimmune Thyroid Diseases |
title | The Emerging Role of Epigenetics in Autoimmune Thyroid Diseases |
title_full | The Emerging Role of Epigenetics in Autoimmune Thyroid Diseases |
title_fullStr | The Emerging Role of Epigenetics in Autoimmune Thyroid Diseases |
title_full_unstemmed | The Emerging Role of Epigenetics in Autoimmune Thyroid Diseases |
title_short | The Emerging Role of Epigenetics in Autoimmune Thyroid Diseases |
title_sort | emerging role of epigenetics in autoimmune thyroid diseases |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383710/ https://www.ncbi.nlm.nih.gov/pubmed/28439272 http://dx.doi.org/10.3389/fimmu.2017.00396 |
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