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Expansion of FasL-Expressing CD5(+) B Cells in Type 1 Diabetes Patients

Fas ligand drives insulitis in the non-obese diabetic mouse model of type 1 diabetes (T1D) and negatively regulates IL-10-producing (IL-10(pos)) CD5(+) B cells in pancreata. Relevance of these phenomena to the human disease is poorly understood. Here, using splenocytes from T1D, autoantibody (Ab(+))...

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Detalles Bibliográficos
Autores principales:	Saxena, Ankit, Yagita, Hideo, Donner, Thomas W., Hamad, Abdel Rahim A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383713/ https://www.ncbi.nlm.nih.gov/pubmed/28439273 http://dx.doi.org/10.3389/fimmu.2017.00402

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