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dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective

Neurons rely on mitochondria as their preferred source of energy. Mutations in PINK1 and PARKIN cause neuronal death in early-onset Parkinson's disease (PD), thought to be due to mitochondrial dysfunction. In Drosophila pink1 and parkin mutants, mitochondrial defects lead to the compensatory up...

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Detalles Bibliográficos
Autores principales:	Celardo, Ivana, Lehmann, Susann, Costa, Ana C, Loh, Samantha HY, Miguel Martins, L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384021/ https://www.ncbi.nlm.nih.gov/pubmed/28211874 http://dx.doi.org/10.1038/cdd.2016.158

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