Epigenetic regulation of HDAC1 SUMOylation as an endogenous neuroprotection against Aβ toxicity in a mouse model of Alzheimer's disease

Amyloid-β (Aβ) produces neurotoxicity in the brain and causes neuronal death, but the endogenous defense mechanism that is activated on Aβ insult is less well known. Here we found that acute Aβ increases the expression of PIAS1 and Mcl-1 via activation of MAPK/ERK, and Aβ induction of PIAS1 enhances...

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Detalles Bibliográficos
Autores principales: Tao, Chih Chieh, Hsu, Wei Lun, Ma, Yun Li, Cheng, Sin Jhong, Lee, Eminy HY
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384022/
https://www.ncbi.nlm.nih.gov/pubmed/28186506
http://dx.doi.org/10.1038/cdd.2016.161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384022/
https://www.ncbi.nlm.nih.gov/pubmed/28186506
http://dx.doi.org/10.1038/cdd.2016.161

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