The involvement of mast cells in the irinotecan-induced enteric neurons loss and reactive gliosis

BACKGROUND: The irinotecan (CPT-11) causes intestinal mucositis and diarrhea that may be related to changes in the enteric nervous system (ENS). In inflammatory condition, mast cells release a variety of pro-inflammatory mediators that can interact with the ENS cells. It has not been explored whethe...

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Detalles Bibliográficos
Autores principales: Nogueira, Ludmila T., Costa, Deiziane V. S., Gomes, Antoniella S., Martins, Conceição S., Silva, Angeline M. H. P., Coelho-Aguiar, Juliana M., Castelucci, Patrícia, Lima-Júnior, Roberto C. P., Leitão, Renata F. C., Moura-Neto, Vivaldo, Brito, Gerly A. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384042/
https://www.ncbi.nlm.nih.gov/pubmed/28388962
http://dx.doi.org/10.1186/s12974-017-0854-1

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