Plk1 Regulates the Repressor Function of FoxM1b by inhibiting its Interaction with the Retinoblastoma Protein

FoxM1b is a cell cycle-regulated transcription factor, whose over-expression is a marker for poor outcome in cancers. Its transcriptional activation function requires phosphorylation by Cdk1 or Cdk2 that primes FoxM1b for phosphorylation by Plk1, which triggers association with the co-activator CBP....

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Detalles Bibliográficos
Autores principales: Mukhopadhyay, Nishit K., Chand, Vaibhav, Pandey, Akshay, Kopanja, Dragana, Carr, Janai R., Chen, Yi-Ju, Liao, Xiubei, Raychaudhuri, Pradip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384083/
https://www.ncbi.nlm.nih.gov/pubmed/28387346
http://dx.doi.org/10.1038/srep46017

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