Detection of prion seeding activity in the olfactory mucosa of patients with Fatal Familial Insomnia

Fatal Familial Insomnia (FFI) is a genetic prion disease caused by a point mutation in the prion protein gene (PRNP) characterized by prominent thalamic atrophy, diffuse astrogliosis and moderate deposition of PrP(Sc) in the brain. Here, for the first time, we demonstrate that the olfactory mucosa (...

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Detalles Bibliográficos
Autores principales: Redaelli, Veronica, Bistaffa, Edoardo, Zanusso, Gianluigi, Salzano, Giulia, Sacchetto, Luca, Rossi, Martina, De Luca, Chiara Maria Giulia, Di Bari, Michele, Portaleone, Sara Maria, Agrimi, Umberto, Legname, Giuseppe, Roiter, Ignazio, Forloni, Gianluigi, Tagliavini, Fabrizio, Moda, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384244/
https://www.ncbi.nlm.nih.gov/pubmed/28387370
http://dx.doi.org/10.1038/srep46269

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