Primate autoimmune disease models; lost for translation?

Replacement, reduction and refinement (the 3R's) are the leading principles in translational research with animals. To be useful a model should also be clinically Relevant (the 4th R). Work in a non-human primate model of multiple sclerosis, the experimental autoimmune encephalomyelitis model,...

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Detalles Bibliográficos
Autor principal: 't Hart, Bert A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Theoretical Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384286/
https://www.ncbi.nlm.nih.gov/pubmed/28435673
http://dx.doi.org/10.1038/cti.2016.82
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description Replacement, reduction and refinement (the 3R's) are the leading principles in translational research with animals. To be useful a model should also be clinically Relevant (the 4th R). Work in a non-human primate model of multiple sclerosis, the experimental autoimmune encephalomyelitis model, reveals an inherent conflict among these 4R principles. The impossibility to harmonize all 4R's forms a major challenge when the model is applied in preclinical drug development.
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spelling pubmed-53842862017-04-23 Primate autoimmune disease models; lost for translation? 't Hart, Bert A Clin Transl Immunology Theoretical Article Replacement, reduction and refinement (the 3R's) are the leading principles in translational research with animals. To be useful a model should also be clinically Relevant (the 4th R). Work in a non-human primate model of multiple sclerosis, the experimental autoimmune encephalomyelitis model, reveals an inherent conflict among these 4R principles. The impossibility to harmonize all 4R's forms a major challenge when the model is applied in preclinical drug development. Nature Publishing Group 2016-12-30 /pmc/articles/PMC5384286/ /pubmed/28435673 http://dx.doi.org/10.1038/cti.2016.82 Text en Copyright © 2016 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Theoretical Article
't Hart, Bert A
Primate autoimmune disease models; lost for translation?
title Primate autoimmune disease models; lost for translation?
title_full Primate autoimmune disease models; lost for translation?
title_fullStr Primate autoimmune disease models; lost for translation?
title_full_unstemmed Primate autoimmune disease models; lost for translation?
title_short Primate autoimmune disease models; lost for translation?
title_sort primate autoimmune disease models; lost for translation?
topic Theoretical Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384286/
https://www.ncbi.nlm.nih.gov/pubmed/28435673
http://dx.doi.org/10.1038/cti.2016.82
work_keys_str_mv AT thartberta primateautoimmunediseasemodelslostfortranslation

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