Cargando…

Stem Cell Differentiation Stage Factors from Zebrafish Embryo: A Novel Strategy to Modulate the Fate of Normal and Pathological Human (Stem) Cells

In spite of the growing body of evidence on the biology of the Zebrafish embryo and stem cells, including the use of Stem Cell Differentiation Stage Factors (SCDSFs) taken from Zebrafish embryo to impact cancer cell dynamics, comparatively little is known about the possibility to use these factors t...

Descripción completa

Detalles Bibliográficos
Autores principales: Biava, Pier M., Canaider, Silvia, Facchin, Federica, Bianconi, Eva, Ljungberg, Liza, Rotilio, Domenico, Burigana, Fabio, Ventura, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384357/
https://www.ncbi.nlm.nih.gov/pubmed/26201607
http://dx.doi.org/10.2174/1389201016666150629102825
_version_ 1782520450221342720
author Biava, Pier M.
Canaider, Silvia
Facchin, Federica
Bianconi, Eva
Ljungberg, Liza
Rotilio, Domenico
Burigana, Fabio
Ventura, Carlo
author_facet Biava, Pier M.
Canaider, Silvia
Facchin, Federica
Bianconi, Eva
Ljungberg, Liza
Rotilio, Domenico
Burigana, Fabio
Ventura, Carlo
author_sort Biava, Pier M.
collection PubMed
description In spite of the growing body of evidence on the biology of the Zebrafish embryo and stem cells, including the use of Stem Cell Differentiation Stage Factors (SCDSFs) taken from Zebrafish embryo to impact cancer cell dynamics, comparatively little is known about the possibility to use these factors to modulate the homeostasis of normal human stem cells or to modulate the behavior of cells involved in different pathological conditions. In the present review we recall in a synthetic way the most important researches about the use of SCDSFs in reprogramming cancer cells and in modulating the high speed of multiplication of keratinocytes which is characteristic of some pathological diseases like psoriasis. Moreover we add here the results about the capability of SCDSFs in modulating the homeostasis of human adipose-derived stem cells (hASCs) isolated from a fat tissue obtained with a novel-non enzymatic method and device. In addition we report the data not yet published about a first protein analysis of the SCDSFs and about their role in a pathological condition like neurodegeneration.
format Online
Article
Text
id pubmed-5384357
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Bentham Science Publishers
record_format MEDLINE/PubMed
spelling pubmed-53843572017-04-12 Stem Cell Differentiation Stage Factors from Zebrafish Embryo: A Novel Strategy to Modulate the Fate of Normal and Pathological Human (Stem) Cells Biava, Pier M. Canaider, Silvia Facchin, Federica Bianconi, Eva Ljungberg, Liza Rotilio, Domenico Burigana, Fabio Ventura, Carlo Curr Pharm Biotechnol Article In spite of the growing body of evidence on the biology of the Zebrafish embryo and stem cells, including the use of Stem Cell Differentiation Stage Factors (SCDSFs) taken from Zebrafish embryo to impact cancer cell dynamics, comparatively little is known about the possibility to use these factors to modulate the homeostasis of normal human stem cells or to modulate the behavior of cells involved in different pathological conditions. In the present review we recall in a synthetic way the most important researches about the use of SCDSFs in reprogramming cancer cells and in modulating the high speed of multiplication of keratinocytes which is characteristic of some pathological diseases like psoriasis. Moreover we add here the results about the capability of SCDSFs in modulating the homeostasis of human adipose-derived stem cells (hASCs) isolated from a fat tissue obtained with a novel-non enzymatic method and device. In addition we report the data not yet published about a first protein analysis of the SCDSFs and about their role in a pathological condition like neurodegeneration. Bentham Science Publishers 2015-09 2015-09 /pmc/articles/PMC5384357/ /pubmed/26201607 http://dx.doi.org/10.2174/1389201016666150629102825 Text en © 2015 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Biava, Pier M.
Canaider, Silvia
Facchin, Federica
Bianconi, Eva
Ljungberg, Liza
Rotilio, Domenico
Burigana, Fabio
Ventura, Carlo
Stem Cell Differentiation Stage Factors from Zebrafish Embryo: A Novel Strategy to Modulate the Fate of Normal and Pathological Human (Stem) Cells
title Stem Cell Differentiation Stage Factors from Zebrafish Embryo: A Novel Strategy to Modulate the Fate of Normal and Pathological Human (Stem) Cells
title_full Stem Cell Differentiation Stage Factors from Zebrafish Embryo: A Novel Strategy to Modulate the Fate of Normal and Pathological Human (Stem) Cells
title_fullStr Stem Cell Differentiation Stage Factors from Zebrafish Embryo: A Novel Strategy to Modulate the Fate of Normal and Pathological Human (Stem) Cells
title_full_unstemmed Stem Cell Differentiation Stage Factors from Zebrafish Embryo: A Novel Strategy to Modulate the Fate of Normal and Pathological Human (Stem) Cells
title_short Stem Cell Differentiation Stage Factors from Zebrafish Embryo: A Novel Strategy to Modulate the Fate of Normal and Pathological Human (Stem) Cells
title_sort stem cell differentiation stage factors from zebrafish embryo: a novel strategy to modulate the fate of normal and pathological human (stem) cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384357/
https://www.ncbi.nlm.nih.gov/pubmed/26201607
http://dx.doi.org/10.2174/1389201016666150629102825
work_keys_str_mv AT biavapierm stemcelldifferentiationstagefactorsfromzebrafishembryoanovelstrategytomodulatethefateofnormalandpathologicalhumanstemcells
AT canaidersilvia stemcelldifferentiationstagefactorsfromzebrafishembryoanovelstrategytomodulatethefateofnormalandpathologicalhumanstemcells
AT facchinfederica stemcelldifferentiationstagefactorsfromzebrafishembryoanovelstrategytomodulatethefateofnormalandpathologicalhumanstemcells
AT bianconieva stemcelldifferentiationstagefactorsfromzebrafishembryoanovelstrategytomodulatethefateofnormalandpathologicalhumanstemcells
AT ljungbergliza stemcelldifferentiationstagefactorsfromzebrafishembryoanovelstrategytomodulatethefateofnormalandpathologicalhumanstemcells
AT rotiliodomenico stemcelldifferentiationstagefactorsfromzebrafishembryoanovelstrategytomodulatethefateofnormalandpathologicalhumanstemcells
AT buriganafabio stemcelldifferentiationstagefactorsfromzebrafishembryoanovelstrategytomodulatethefateofnormalandpathologicalhumanstemcells
AT venturacarlo stemcelldifferentiationstagefactorsfromzebrafishembryoanovelstrategytomodulatethefateofnormalandpathologicalhumanstemcells