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A diffuse lung emphysema, severe pulmonary hypertension and lack of airflow limitation

Pulmonary veno-occlusive disease is characterized by remodeling of pulmonary arteries, capillaries and venules. We report a case of diffuse lung emphysema and pulmonary veno-occlusive disease with the characteristic of having no airflow limitation. A very low diffusing capacity for carbon monoxide a...

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Autores principales: Faure, Morgane, Gomez, Emmanuel, Dorfmüller, Peter, Mandry, Damien, Canuet, Matthieu, Kessler, Romain, Chabot, François, Chaouat, Ari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384413/
https://www.ncbi.nlm.nih.gov/pubmed/28413774
http://dx.doi.org/10.1016/j.rmcr.2017.04.001
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author Faure, Morgane
Gomez, Emmanuel
Dorfmüller, Peter
Mandry, Damien
Canuet, Matthieu
Kessler, Romain
Chabot, François
Chaouat, Ari
author_facet Faure, Morgane
Gomez, Emmanuel
Dorfmüller, Peter
Mandry, Damien
Canuet, Matthieu
Kessler, Romain
Chabot, François
Chaouat, Ari
author_sort Faure, Morgane
collection PubMed
description Pulmonary veno-occlusive disease is characterized by remodeling of pulmonary arteries, capillaries and venules. We report a case of diffuse lung emphysema and pulmonary veno-occlusive disease with the characteristic of having no airflow limitation. A very low diffusing capacity for carbon monoxide and results of high-resolution computed tomography of the chest suggested pulmonary veno-occlusive disease. The diagnosis was confirmed on histological analysis after lung transplantation. The combination of results of the computed tomography of the chest and the histological analysis suggested a relationship between diffuse lung emphysema and remodeling of pulmonary vessels. A distinctive pattern of mild-to-moderate airflow limitation in patients with chronic obstructive pulmonary disease and severe pulmonary hypertension has been described. This observation of the combination of diffuse emphysema, pulmonary veno-occlusive disease and no airflow limitation supports further pathophysiological studies on severe pulmonary hypertension in chronic obstructive pulmonary disease.
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spelling pubmed-53844132017-04-14 A diffuse lung emphysema, severe pulmonary hypertension and lack of airflow limitation Faure, Morgane Gomez, Emmanuel Dorfmüller, Peter Mandry, Damien Canuet, Matthieu Kessler, Romain Chabot, François Chaouat, Ari Respir Med Case Rep Case Report Pulmonary veno-occlusive disease is characterized by remodeling of pulmonary arteries, capillaries and venules. We report a case of diffuse lung emphysema and pulmonary veno-occlusive disease with the characteristic of having no airflow limitation. A very low diffusing capacity for carbon monoxide and results of high-resolution computed tomography of the chest suggested pulmonary veno-occlusive disease. The diagnosis was confirmed on histological analysis after lung transplantation. The combination of results of the computed tomography of the chest and the histological analysis suggested a relationship between diffuse lung emphysema and remodeling of pulmonary vessels. A distinctive pattern of mild-to-moderate airflow limitation in patients with chronic obstructive pulmonary disease and severe pulmonary hypertension has been described. This observation of the combination of diffuse emphysema, pulmonary veno-occlusive disease and no airflow limitation supports further pathophysiological studies on severe pulmonary hypertension in chronic obstructive pulmonary disease. Elsevier 2017-04-04 /pmc/articles/PMC5384413/ /pubmed/28413774 http://dx.doi.org/10.1016/j.rmcr.2017.04.001 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Faure, Morgane
Gomez, Emmanuel
Dorfmüller, Peter
Mandry, Damien
Canuet, Matthieu
Kessler, Romain
Chabot, François
Chaouat, Ari
A diffuse lung emphysema, severe pulmonary hypertension and lack of airflow limitation
title A diffuse lung emphysema, severe pulmonary hypertension and lack of airflow limitation
title_full A diffuse lung emphysema, severe pulmonary hypertension and lack of airflow limitation
title_fullStr A diffuse lung emphysema, severe pulmonary hypertension and lack of airflow limitation
title_full_unstemmed A diffuse lung emphysema, severe pulmonary hypertension and lack of airflow limitation
title_short A diffuse lung emphysema, severe pulmonary hypertension and lack of airflow limitation
title_sort diffuse lung emphysema, severe pulmonary hypertension and lack of airflow limitation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384413/
https://www.ncbi.nlm.nih.gov/pubmed/28413774
http://dx.doi.org/10.1016/j.rmcr.2017.04.001
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