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The role of WRNIP1 in genome maintenance
WRNIP1 interacts with WRN helicase, which is defective in the premature aging disease Werner syndrome. WRNIP1 belongs to the AAA+ ATPase family and is conserved from Escherichia coli to human. The protein contains an ubiquitin-binding zinc finger (UBZ) domain at the N terminus and an ATPase domain i...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384577/ https://www.ncbi.nlm.nih.gov/pubmed/28118071 http://dx.doi.org/10.1080/15384101.2017.1282585 |
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author | Yoshimura, Akari Seki, Masayuki Enomoto, Takemi |
author_facet | Yoshimura, Akari Seki, Masayuki Enomoto, Takemi |
author_sort | Yoshimura, Akari |
collection | PubMed |
description | WRNIP1 interacts with WRN helicase, which is defective in the premature aging disease Werner syndrome. WRNIP1 belongs to the AAA+ ATPase family and is conserved from Escherichia coli to human. The protein contains an ubiquitin-binding zinc finger (UBZ) domain at the N terminus and an ATPase domain in the middle region. In addition to WRN, WRNIP1 interacts with proteins involved in multiple cellular pathways, including RAD18, monoubiquitylated PCNA, DNA polymerase δ, RAD51, and ATMIN. Mgs1, the yeast homolog of WRNIP1, may act downstream of ubiquitylation of PCNA to mobilize DNA polymerase δ. By contrast, the functions of WRNIP1 in higher eukaryotic cells remain obscure, although data regarding the roles of WRNIP1 in DNA transactions have emerged recently. Here, we first describe the functions of Mgs1 in DNA transaction. We then describe various features of WRNIP1 and discuss its possible roles based on recent studies of the function of WRNIP1. |
format | Online Article Text |
id | pubmed-5384577 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-53845772017-04-12 The role of WRNIP1 in genome maintenance Yoshimura, Akari Seki, Masayuki Enomoto, Takemi Cell Cycle Review WRNIP1 interacts with WRN helicase, which is defective in the premature aging disease Werner syndrome. WRNIP1 belongs to the AAA+ ATPase family and is conserved from Escherichia coli to human. The protein contains an ubiquitin-binding zinc finger (UBZ) domain at the N terminus and an ATPase domain in the middle region. In addition to WRN, WRNIP1 interacts with proteins involved in multiple cellular pathways, including RAD18, monoubiquitylated PCNA, DNA polymerase δ, RAD51, and ATMIN. Mgs1, the yeast homolog of WRNIP1, may act downstream of ubiquitylation of PCNA to mobilize DNA polymerase δ. By contrast, the functions of WRNIP1 in higher eukaryotic cells remain obscure, although data regarding the roles of WRNIP1 in DNA transactions have emerged recently. Here, we first describe the functions of Mgs1 in DNA transaction. We then describe various features of WRNIP1 and discuss its possible roles based on recent studies of the function of WRNIP1. Taylor & Francis 2017-01-24 /pmc/articles/PMC5384577/ /pubmed/28118071 http://dx.doi.org/10.1080/15384101.2017.1282585 Text en © 2017 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
spellingShingle | Review Yoshimura, Akari Seki, Masayuki Enomoto, Takemi The role of WRNIP1 in genome maintenance |
title | The role of WRNIP1 in genome maintenance |
title_full | The role of WRNIP1 in genome maintenance |
title_fullStr | The role of WRNIP1 in genome maintenance |
title_full_unstemmed | The role of WRNIP1 in genome maintenance |
title_short | The role of WRNIP1 in genome maintenance |
title_sort | role of wrnip1 in genome maintenance |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384577/ https://www.ncbi.nlm.nih.gov/pubmed/28118071 http://dx.doi.org/10.1080/15384101.2017.1282585 |
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