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Clinical course and outcome of patients with high-level microsatellite instability cancers in a real-life setting: a retrospective analysis

BACKGROUND: The prognostic and predictive significance of the high-level microsatellite instability (MSI-H) phenotype in various malignancies is unclear. We describe the characteristics, clinical course, and outcomes of patients with MSI-H malignancies treated in a real-life hospital setting. PATIEN...

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Autores principales: Halpern, Naama, Goldberg, Yael, Kadouri, Luna, Duvdevani, Morasha, Hamburger, Tamar, Peretz, Tamar, Hubert, Ayala
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384685/
https://www.ncbi.nlm.nih.gov/pubmed/28408840
http://dx.doi.org/10.2147/OTT.S126905
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author Halpern, Naama
Goldberg, Yael
Kadouri, Luna
Duvdevani, Morasha
Hamburger, Tamar
Peretz, Tamar
Hubert, Ayala
author_facet Halpern, Naama
Goldberg, Yael
Kadouri, Luna
Duvdevani, Morasha
Hamburger, Tamar
Peretz, Tamar
Hubert, Ayala
author_sort Halpern, Naama
collection PubMed
description BACKGROUND: The prognostic and predictive significance of the high-level microsatellite instability (MSI-H) phenotype in various malignancies is unclear. We describe the characteristics, clinical course, and outcomes of patients with MSI-H malignancies treated in a real-life hospital setting. PATIENTS AND METHODS: A retrospective analysis of MSI-H cancer patient files was conducted. We analyzed the genetic data, clinical characteristics, and oncological treatments, including chemotherapy and surgical interventions. RESULTS: Clinical data of 73 MSI-H cancer patients were available. Mean age at diagnosis of first malignancy was 52.3 years. Eight patients (11%) had more than four malignancies each. Most patients (76%) had colorectal cancer (CRC). Seventeen patients (23%) had only extracolonic malignancies. Eighteen women (36%) had gynecological malignancy. Nine women (18%) had breast cancer. Mean follow-up was 8.5 years. Five-year overall survival and disease-free survival of all MSI-H cancer patients from first malignancy were 86% and 74.6%, respectively. Five-year overall survival rates of stage 2, 3, and 4 MSI-H CRC patients were 89.5%, 58.4%, and 22.9%, respectively. CONCLUSION: Although the overall prognosis of MSI-H cancer patients is favorable, this advantage may not be maintained in advanced MSI-H CRC patients.
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spelling pubmed-53846852017-04-13 Clinical course and outcome of patients with high-level microsatellite instability cancers in a real-life setting: a retrospective analysis Halpern, Naama Goldberg, Yael Kadouri, Luna Duvdevani, Morasha Hamburger, Tamar Peretz, Tamar Hubert, Ayala Onco Targets Ther Original Research BACKGROUND: The prognostic and predictive significance of the high-level microsatellite instability (MSI-H) phenotype in various malignancies is unclear. We describe the characteristics, clinical course, and outcomes of patients with MSI-H malignancies treated in a real-life hospital setting. PATIENTS AND METHODS: A retrospective analysis of MSI-H cancer patient files was conducted. We analyzed the genetic data, clinical characteristics, and oncological treatments, including chemotherapy and surgical interventions. RESULTS: Clinical data of 73 MSI-H cancer patients were available. Mean age at diagnosis of first malignancy was 52.3 years. Eight patients (11%) had more than four malignancies each. Most patients (76%) had colorectal cancer (CRC). Seventeen patients (23%) had only extracolonic malignancies. Eighteen women (36%) had gynecological malignancy. Nine women (18%) had breast cancer. Mean follow-up was 8.5 years. Five-year overall survival and disease-free survival of all MSI-H cancer patients from first malignancy were 86% and 74.6%, respectively. Five-year overall survival rates of stage 2, 3, and 4 MSI-H CRC patients were 89.5%, 58.4%, and 22.9%, respectively. CONCLUSION: Although the overall prognosis of MSI-H cancer patients is favorable, this advantage may not be maintained in advanced MSI-H CRC patients. Dove Medical Press 2017-03-29 /pmc/articles/PMC5384685/ /pubmed/28408840 http://dx.doi.org/10.2147/OTT.S126905 Text en © 2017 Halpern et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Halpern, Naama
Goldberg, Yael
Kadouri, Luna
Duvdevani, Morasha
Hamburger, Tamar
Peretz, Tamar
Hubert, Ayala
Clinical course and outcome of patients with high-level microsatellite instability cancers in a real-life setting: a retrospective analysis
title Clinical course and outcome of patients with high-level microsatellite instability cancers in a real-life setting: a retrospective analysis
title_full Clinical course and outcome of patients with high-level microsatellite instability cancers in a real-life setting: a retrospective analysis
title_fullStr Clinical course and outcome of patients with high-level microsatellite instability cancers in a real-life setting: a retrospective analysis
title_full_unstemmed Clinical course and outcome of patients with high-level microsatellite instability cancers in a real-life setting: a retrospective analysis
title_short Clinical course and outcome of patients with high-level microsatellite instability cancers in a real-life setting: a retrospective analysis
title_sort clinical course and outcome of patients with high-level microsatellite instability cancers in a real-life setting: a retrospective analysis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384685/
https://www.ncbi.nlm.nih.gov/pubmed/28408840
http://dx.doi.org/10.2147/OTT.S126905
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