Modulation of the activity of N-methyl-d-aspartate receptors as a novel treatment option for depression: current clinical evidence and therapeutic potential of rapastinel (GLYX-13)

Classical monoaminergic antidepressants show several disadvantages, such as protracted onset of therapeutic action. Conversely, the fast and sustained antidepressant effect of the N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine raises vast interest in understanding the role of the glutamat...

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Detalles Bibliográficos
Autores principales: Vasilescu, Andrei-Nicolae, Schweinfurth, Nina, Borgwardt, Stefan, Gass, Peter, Lang, Undine E, Inta, Dragos, Eckart, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384686/
https://www.ncbi.nlm.nih.gov/pubmed/28408831
http://dx.doi.org/10.2147/NDT.S119004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384686/
https://www.ncbi.nlm.nih.gov/pubmed/28408831
http://dx.doi.org/10.2147/NDT.S119004

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