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Modulation of the activity of N-methyl-d-aspartate receptors as a novel treatment option for depression: current clinical evidence and therapeutic potential of rapastinel (GLYX-13)

Classical monoaminergic antidepressants show several disadvantages, such as protracted onset of therapeutic action. Conversely, the fast and sustained antidepressant effect of the N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine raises vast interest in understanding the role of the glutamat...

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Detalles Bibliográficos
Autores principales:	Vasilescu, Andrei-Nicolae, Schweinfurth, Nina, Borgwardt, Stefan, Gass, Peter, Lang, Undine E, Inta, Dragos, Eckart, Sarah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384686/ https://www.ncbi.nlm.nih.gov/pubmed/28408831 http://dx.doi.org/10.2147/NDT.S119004

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