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Embryonic transcription factor expression in mice predicts medial amygdala neuronal identity and sex-specific responses to innate behavioral cues

The medial subnucleus of the amygdala (MeA) plays a central role in processing sensory cues required for innate behaviors. However, whether there is a link between developmental programs and the emergence of inborn behaviors remains unknown. Our previous studies revealed that the telencephalic preop...

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Autores principales: Lischinsky, Julieta E, Sokolowski, Katie, Li, Peijun, Esumi, Shigeyuki, Kamal, Yasmin, Goodrich, Meredith, Oboti, Livio, Hammond, Timothy R, Krishnamoorthy, Meera, Feldman, Daniel, Huntsman, Molly, Liu, Judy, Corbin, Joshua G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384829/
https://www.ncbi.nlm.nih.gov/pubmed/28244870
http://dx.doi.org/10.7554/eLife.21012
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author Lischinsky, Julieta E
Sokolowski, Katie
Li, Peijun
Esumi, Shigeyuki
Kamal, Yasmin
Goodrich, Meredith
Oboti, Livio
Hammond, Timothy R
Krishnamoorthy, Meera
Feldman, Daniel
Huntsman, Molly
Liu, Judy
Corbin, Joshua G
author_facet Lischinsky, Julieta E
Sokolowski, Katie
Li, Peijun
Esumi, Shigeyuki
Kamal, Yasmin
Goodrich, Meredith
Oboti, Livio
Hammond, Timothy R
Krishnamoorthy, Meera
Feldman, Daniel
Huntsman, Molly
Liu, Judy
Corbin, Joshua G
author_sort Lischinsky, Julieta E
collection PubMed
description The medial subnucleus of the amygdala (MeA) plays a central role in processing sensory cues required for innate behaviors. However, whether there is a link between developmental programs and the emergence of inborn behaviors remains unknown. Our previous studies revealed that the telencephalic preoptic area (POA) embryonic niche is a novel source of MeA destined progenitors. Here, we show that the POA is comprised of distinct progenitor pools complementarily marked by the transcription factors Dbx1 and Foxp2. As determined by molecular and electrophysiological criteria this embryonic parcellation predicts postnatal MeA inhibitory neuronal subtype identity. We further find that Dbx1-derived and Foxp2+ cells in the MeA are differentially activated in response to innate behavioral cues in a sex-specific manner. Thus, developmental transcription factor expression is predictive of MeA neuronal identity and sex-specific neuronal responses, providing a potential developmental logic for how innate behaviors could be processed by different MeA neuronal subtypes. DOI: http://dx.doi.org/10.7554/eLife.21012.001
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spelling pubmed-53848292017-04-10 Embryonic transcription factor expression in mice predicts medial amygdala neuronal identity and sex-specific responses to innate behavioral cues Lischinsky, Julieta E Sokolowski, Katie Li, Peijun Esumi, Shigeyuki Kamal, Yasmin Goodrich, Meredith Oboti, Livio Hammond, Timothy R Krishnamoorthy, Meera Feldman, Daniel Huntsman, Molly Liu, Judy Corbin, Joshua G eLife Neuroscience The medial subnucleus of the amygdala (MeA) plays a central role in processing sensory cues required for innate behaviors. However, whether there is a link between developmental programs and the emergence of inborn behaviors remains unknown. Our previous studies revealed that the telencephalic preoptic area (POA) embryonic niche is a novel source of MeA destined progenitors. Here, we show that the POA is comprised of distinct progenitor pools complementarily marked by the transcription factors Dbx1 and Foxp2. As determined by molecular and electrophysiological criteria this embryonic parcellation predicts postnatal MeA inhibitory neuronal subtype identity. We further find that Dbx1-derived and Foxp2+ cells in the MeA are differentially activated in response to innate behavioral cues in a sex-specific manner. Thus, developmental transcription factor expression is predictive of MeA neuronal identity and sex-specific neuronal responses, providing a potential developmental logic for how innate behaviors could be processed by different MeA neuronal subtypes. DOI: http://dx.doi.org/10.7554/eLife.21012.001 eLife Sciences Publications, Ltd 2017-03-13 /pmc/articles/PMC5384829/ /pubmed/28244870 http://dx.doi.org/10.7554/eLife.21012 Text en © 2017, Lischinsky et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Lischinsky, Julieta E
Sokolowski, Katie
Li, Peijun
Esumi, Shigeyuki
Kamal, Yasmin
Goodrich, Meredith
Oboti, Livio
Hammond, Timothy R
Krishnamoorthy, Meera
Feldman, Daniel
Huntsman, Molly
Liu, Judy
Corbin, Joshua G
Embryonic transcription factor expression in mice predicts medial amygdala neuronal identity and sex-specific responses to innate behavioral cues
title Embryonic transcription factor expression in mice predicts medial amygdala neuronal identity and sex-specific responses to innate behavioral cues
title_full Embryonic transcription factor expression in mice predicts medial amygdala neuronal identity and sex-specific responses to innate behavioral cues
title_fullStr Embryonic transcription factor expression in mice predicts medial amygdala neuronal identity and sex-specific responses to innate behavioral cues
title_full_unstemmed Embryonic transcription factor expression in mice predicts medial amygdala neuronal identity and sex-specific responses to innate behavioral cues
title_short Embryonic transcription factor expression in mice predicts medial amygdala neuronal identity and sex-specific responses to innate behavioral cues
title_sort embryonic transcription factor expression in mice predicts medial amygdala neuronal identity and sex-specific responses to innate behavioral cues
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384829/
https://www.ncbi.nlm.nih.gov/pubmed/28244870
http://dx.doi.org/10.7554/eLife.21012
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