Cargando…

Levodopa/carbidopa microtablets in Parkinson’s disease: a study of pharmacokinetics and blinded motor assessment

BACKGROUND: Motor function assessments with rating scales in relation to the pharmacokinetics of levodopa may increase the understanding of how to individualize and fine-tune treatments. OBJECTIVES: This study aimed to investigate the pharmacokinetic profiles of levodopa-carbidopa and the motor func...

Descripción completa

Detalles Bibliográficos
Autores principales:	Senek, Marina, Aquilonius, Sten-Magnus, Askmark, Håkan, Bergquist, Filip, Constantinescu, Radu, Ericsson, Anders, Lycke, Sara, Medvedev, Alexander, Memedi, Mevludin, Ohlsson, Fredrik, Spira, Jack, Westin, Jerker, Nyholm, Dag
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2017
Materias:	Pharmacokinetics and Disposition
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384948/ https://www.ncbi.nlm.nih.gov/pubmed/28101657 http://dx.doi.org/10.1007/s00228-017-2196-4

Ejemplares similares

Population pharmacokinetics of levodopa/carbidopa microtablets in healthy subjects and Parkinson’s disease patients
por: Senek, Marina, et al.
Publicado: (2018)

Sensor-based algorithmic dosing suggestions for oral administration of levodopa/carbidopa microtablets for Parkinson’s disease: a first experience
por: Thomas, Ilias, et al.
Publicado: (2019)

Comparison of the pharmacokinetics of an oral extended‐release capsule formulation of carbidopa‐levodopa (IPX066) with immediate‐release carbidopa‐levodopa (Sinemet(®)), sustained‐release carbidopa‐levodopa (Sinemet(®) CR), and carbidopa‐levodopa‐entacapone (Stalevo(®))
por: Hsu, Ann, et al.
Publicado: (2015)

Personalized Medicine Approach in Treating Parkinson’s Disease, Using Oral Administration of Levodopa/Carbidopa Microtablets in Clinical Practice
por: Grétarsdóttir, Helga María, et al.
Publicado: (2021)

Population pharmacokinetics of levodopa in subjects with advanced Parkinson's disease: levodopa-carbidopa intestinal gel infusion vs. oral tablets
por: Othman, Ahmed A, et al.
Publicado: (2014)

Pharmacokinetics and tolerability of artesunate and amodiaquine alone and in combination in healthy volunteers
por: Orrell, Catherine, et al.
Publicado: (2008)

Evaluation of limited sampling strategies for tacrolimus
por: Op den Buijsch, Robert A. M., et al.
Publicado: (2007)

Effects of erythromycin on voriconazole pharmacokinetics and association with CYP2C19 polymorphism
por: Shi, Hui-Yan, et al.
Publicado: (2010)

Pharmacokinetics of gemcitabine in non-small-cell lung cancer patients: impact of the 79A>C cytidine deaminase polymorphism
por: Maring, Jan Gerard, et al.
Publicado: (2010)

Tolerability and pharmacokinetics of non-fixed and fixed combinations of artesunate and amodiaquine in Malaysian healthy normal volunteers
por: Navaratnam, Visweswaran, et al.
Publicado: (2009)

Comparison of plasma, venous and capillary blood levels of piperaquine in patients with uncomplicated falciparum malaria
por: Ashley, Elizabeth A., et al.
Publicado: (2010)

Influences on the pharmacokinetics of oxycodone: a multicentre cross-sectional study in 439 adult cancer patients
por: Andreassen, Trine Naalsund, et al.
Publicado: (2010)

Ontogeny of midazolam glucuronidation in preterm infants
por: de Wildt, Saskia N., et al.
Publicado: (2009)

Pancytopenia due to proguanil toxicity in a returning traveller with fever
por: Jolink, Hetty, et al.
Publicado: (2010)

Population pharmacokinetic analysis of infliximab in patients with ulcerative colitis
por: Fasanmade, Adedigbo A., et al.
Publicado: (2009)

Population pharmacokinetics of phenytoin after intravenous administration of fosphenytoin sodium in pediatric patients, adult patients, and healthy volunteers
por: Tanaka, Jun, et al.
Publicado: (2012)

VKORC1-dependent pharmacokinetics of intravenous and oral phylloquinone (vitamin K1) mixed micelles formulation
por: Marinova, Milka, et al.
Publicado: (2012)

Pharmacokinetics and pharmacodynamics of moist inhalation epinephrine using a mobile inhaler
por: Breuer, C., et al.
Publicado: (2013)

Importance of hematocrit for a tacrolimus target concentration strategy
por: Størset, Elisabet, et al.
Publicado: (2013)

Pharmacokinetics of intravenous telavancin in healthy subjects with varying degrees of renal impairment
por: Worboys, Philip D., et al.
Publicado: (2015)

Investigation into the interchangeability of generic formulations using immunosuppressants and a broad selection of medicines
por: Yu, Yang, et al.
Publicado: (2015)

Developmental changes rather than repeated administration drive paracetamol glucuronidation in neonates and infants
por: Krekels, Elke H. J., et al.
Publicado: (2015)

A pharmacometric pulmonary model predicting the extent and rate of distribution from plasma to epithelial lining fluid and alveolar cells—using rifampicin as an example
por: Clewe, Oskar, et al.
Publicado: (2015)

Effect of hepatic or renal impairment on the pharmacokinetics of evacetrapib
por: Small, David S., et al.
Publicado: (2016)

A clinically relevant pharmacokinetic interaction between cyclosporine and imatinib
por: Atiq, Ferdows, et al.
Publicado: (2016)

The effect of dipyridamole on the pharmacokinetics of metformin: a randomized crossover study in healthy volunteers
por: El Messaoudi, S., et al.
Publicado: (2016)

Treatment with subcutaneous and transdermal fentanyl: results from a population pharmacokinetic study in cancer patients
por: Oosten, Astrid W., et al.
Publicado: (2016)

Single-dose pharmacokinetics and safety of azilsartan medoxomil in children and adolescents with hypertension as compared to healthy adults
por: Webb, Nicholas J. A., et al.
Publicado: (2016)

Plasma pharmacokinetics and synovial concentrations of S-flurbiprofen plaster in humans
por: Yataba, Ikuko, et al.
Publicado: (2015)

Hair analysis for detection of triptans occasionally used or overused by migraine patients—a pilot study
por: Ferrari, Anna, et al.
Publicado: (2016)

Prediction of drug interaction between oral adsorbent AST-120 and concomitant drugs based on the in vitro dissolution and in vivo absorption behavior of the drugs
por: Koya, Yohei, et al.
Publicado: (2016)

Use of population approach non-linear mixed effects models in the evaluation of biosimilarity of monoclonal antibodies
por: Reijers, Joannes A. A., et al.
Publicado: (2016)

Monitoring of adherence to headache treatments by means of hair analysis
por: Ferrari, Anna, et al.
Publicado: (2016)

Effects of cytochrome P450 (CYP3A4 and CYP2C19) inhibition and induction on the exposure of selumetinib, a MEK1/2 inhibitor, in healthy subjects: results from two clinical trials
por: Dymond, Angela W., et al.
Publicado: (2016)

Clinical validation study of dried blood spot for determining everolimus concentration in patients with cancer
por: Willemsen, A. E. C. A. B., et al.
Publicado: (2017)

Influence of genetic co-factors on the population pharmacokinetic model for clopidogrel and its active thiol metabolite
por: Danielak, Dorota, et al.
Publicado: (2017)

Pharmacokinetics of doripenem in plasma and epithelial lining fluid (ELF): comparison of two dosage regimens
por: Oesterreicher, Zoe, et al.
Publicado: (2017)

Pharmacokinetic drug interaction and safety after coadministration of clarithromycin, amoxicillin, and ilaprazole: a randomised, open-label, one-way crossover, two parallel sequences study
por: Jin, Byung Hak, et al.
Publicado: (2018)

Pharmacokinetics and pharmacodynamics of ticagrelor in subjects on hemodialysis and subjects with normal renal function
por: Teng, Renli, et al.
Publicado: (2018)

Population pharmacokinetics of treosulfan and development of a limited sampling strategy in children prior to hematopoietic stem cell transplantation
por: Danielak, Dorota, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_i07tmk62c1a5ccf9q88fi8hnn1