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Enthalpy–entropy compensation: the role of solvation

Structural modifications to interacting systems frequently lead to changes in both the enthalpy (heat) and entropy of the process that compensate each other, so that the Gibbs free energy is little changed: a major barrier to the development of lead compounds in drug discovery. The conventional expl...

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Detalles Bibliográficos
Autores principales:	Dragan, Anatoliy I., Read, Christopher M., Crane-Robinson, Colyn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2016
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384952/ https://www.ncbi.nlm.nih.gov/pubmed/27796417 http://dx.doi.org/10.1007/s00249-016-1182-6

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