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Cardiac Biomarkers and the Diagnosis of Myocardial Infarction in Women
PURPOSE OF REVIEW: Women with suspected acute coronary syndrome are less likely to undergo investigation or receive treatment than men, and women consistently have poorer outcomes. This review summarises how the latest development in cardiac biomarkers could improve both diagnosis and outcomes in wo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385194/ https://www.ncbi.nlm.nih.gov/pubmed/28391559 http://dx.doi.org/10.1007/s11886-017-0839-9 |
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author | Shah, Anoop S. V. Ferry, Amy V. Mills, Nicholas L. |
author_facet | Shah, Anoop S. V. Ferry, Amy V. Mills, Nicholas L. |
author_sort | Shah, Anoop S. V. |
collection | PubMed |
description | PURPOSE OF REVIEW: Women with suspected acute coronary syndrome are less likely to undergo investigation or receive treatment than men, and women consistently have poorer outcomes. This review summarises how the latest development in cardiac biomarkers could improve both diagnosis and outcomes in women. RECENT FINDINGS: Novel high-sensitivity cardiac troponin assays have identified differences in the reference range and therefore diagnostic threshold for myocardial infarction in men and women. These differences are present across multiple populations with different ethnic backgrounds and for a range of assays. The use of a uniform threshold for cardiac troponin does not provide equivalent prediction in men and women, with lower thresholds needed for women to provide comparable risk stratification. SUMMARY: Sex differences in cardiac troponin concentrations are not widely recognised in clinical practice and may be contributing to the under-diagnosis of myocardial infarction in women and discrepancies in patient care and outcomes. |
format | Online Article Text |
id | pubmed-5385194 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-53851942017-04-24 Cardiac Biomarkers and the Diagnosis of Myocardial Infarction in Women Shah, Anoop S. V. Ferry, Amy V. Mills, Nicholas L. Curr Cardiol Rep Management of Acute Coronary Syndromes (AS Jaffe, Section Editor) PURPOSE OF REVIEW: Women with suspected acute coronary syndrome are less likely to undergo investigation or receive treatment than men, and women consistently have poorer outcomes. This review summarises how the latest development in cardiac biomarkers could improve both diagnosis and outcomes in women. RECENT FINDINGS: Novel high-sensitivity cardiac troponin assays have identified differences in the reference range and therefore diagnostic threshold for myocardial infarction in men and women. These differences are present across multiple populations with different ethnic backgrounds and for a range of assays. The use of a uniform threshold for cardiac troponin does not provide equivalent prediction in men and women, with lower thresholds needed for women to provide comparable risk stratification. SUMMARY: Sex differences in cardiac troponin concentrations are not widely recognised in clinical practice and may be contributing to the under-diagnosis of myocardial infarction in women and discrepancies in patient care and outcomes. Springer US 2017-04-08 2017 /pmc/articles/PMC5385194/ /pubmed/28391559 http://dx.doi.org/10.1007/s11886-017-0839-9 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Management of Acute Coronary Syndromes (AS Jaffe, Section Editor) Shah, Anoop S. V. Ferry, Amy V. Mills, Nicholas L. Cardiac Biomarkers and the Diagnosis of Myocardial Infarction in Women |
title | Cardiac Biomarkers and the Diagnosis of Myocardial Infarction in Women |
title_full | Cardiac Biomarkers and the Diagnosis of Myocardial Infarction in Women |
title_fullStr | Cardiac Biomarkers and the Diagnosis of Myocardial Infarction in Women |
title_full_unstemmed | Cardiac Biomarkers and the Diagnosis of Myocardial Infarction in Women |
title_short | Cardiac Biomarkers and the Diagnosis of Myocardial Infarction in Women |
title_sort | cardiac biomarkers and the diagnosis of myocardial infarction in women |
topic | Management of Acute Coronary Syndromes (AS Jaffe, Section Editor) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385194/ https://www.ncbi.nlm.nih.gov/pubmed/28391559 http://dx.doi.org/10.1007/s11886-017-0839-9 |
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