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Effects of coenzyme Q(10) on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity

The study was performed to see the effects of coenzyme Q(10) (CoQ(10)) on blood biochemical components and hepatic antioxidant system in rats exposed to lipopolysaccharide (LPS)-induced toxicity. A total of 24 rats were allocated to four groups: control (CON), 100 mg/kg BW of LPS (LPS), 100 mg of Co...

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Autores principales: Song, Min-Hae, Kim, Ha-Na, Lim, Yong, Jang, In-Surk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association for Laboratory Animal Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385279/
https://www.ncbi.nlm.nih.gov/pubmed/28400836
http://dx.doi.org/10.5625/lar.2017.33.1.24
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author Song, Min-Hae
Kim, Ha-Na
Lim, Yong
Jang, In-Surk
author_facet Song, Min-Hae
Kim, Ha-Na
Lim, Yong
Jang, In-Surk
author_sort Song, Min-Hae
collection PubMed
description The study was performed to see the effects of coenzyme Q(10) (CoQ(10)) on blood biochemical components and hepatic antioxidant system in rats exposed to lipopolysaccharide (LPS)-induced toxicity. A total of 24 rats were allocated to four groups: control (CON), 100 mg/kg BW of LPS (LPS), 100 mg of CoQ(10)/kg BW with LPS (LCQI) and 300 mg of CoQ(10)/kg BW with LPS (LCQII). The LPS and LCQI groups showed a significant (P<0.05) increase in the relative spleen weight compared with the CON group without affecting body and liver weights. The blood alanine aminotransferase (ALT) level in the LPS group was significantly (P<0.05) greater than that in the CON group, while supplementation with 100 or 300 mg CoQ(10) to rats injected with LPS normalized the ALT level in the CON group. In antioxidant systems, the LPS group showed a significantly (P<0.05) higher mRNA and activity of superoxide dismutase (SOD) than the CON group. The supplementation with CoQ(10) to the LPS-treated group normalized the level of SOD, which was comparable to the level of the CON group. Both the mRNA expression and activity of glutathione peroxidase in the LCQI and LCQII groups were higher (P<0.05) than that of the LPS group. However, administration of LPS or CoQ(10) unaffected the level of catalase and total antioxidant power. The level of lipid peroxidation in the LCQII group was lower (P<0.05) than that in the LPS group. In conclusion, CoQ(10) exerted its favorable effect against liver damage by modulation of antioxidant enzymes in LPS treated rats.
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spelling pubmed-53852792017-04-11 Effects of coenzyme Q(10) on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity Song, Min-Hae Kim, Ha-Na Lim, Yong Jang, In-Surk Lab Anim Res Original Article The study was performed to see the effects of coenzyme Q(10) (CoQ(10)) on blood biochemical components and hepatic antioxidant system in rats exposed to lipopolysaccharide (LPS)-induced toxicity. A total of 24 rats were allocated to four groups: control (CON), 100 mg/kg BW of LPS (LPS), 100 mg of CoQ(10)/kg BW with LPS (LCQI) and 300 mg of CoQ(10)/kg BW with LPS (LCQII). The LPS and LCQI groups showed a significant (P<0.05) increase in the relative spleen weight compared with the CON group without affecting body and liver weights. The blood alanine aminotransferase (ALT) level in the LPS group was significantly (P<0.05) greater than that in the CON group, while supplementation with 100 or 300 mg CoQ(10) to rats injected with LPS normalized the ALT level in the CON group. In antioxidant systems, the LPS group showed a significantly (P<0.05) higher mRNA and activity of superoxide dismutase (SOD) than the CON group. The supplementation with CoQ(10) to the LPS-treated group normalized the level of SOD, which was comparable to the level of the CON group. Both the mRNA expression and activity of glutathione peroxidase in the LCQI and LCQII groups were higher (P<0.05) than that of the LPS group. However, administration of LPS or CoQ(10) unaffected the level of catalase and total antioxidant power. The level of lipid peroxidation in the LCQII group was lower (P<0.05) than that in the LPS group. In conclusion, CoQ(10) exerted its favorable effect against liver damage by modulation of antioxidant enzymes in LPS treated rats. Korean Association for Laboratory Animal Science 2017-03 2017-03-27 /pmc/articles/PMC5385279/ /pubmed/28400836 http://dx.doi.org/10.5625/lar.2017.33.1.24 Text en Copyright © 2017 Korean Association for Laboratory Animal Science http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Song, Min-Hae
Kim, Ha-Na
Lim, Yong
Jang, In-Surk
Effects of coenzyme Q(10) on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity
title Effects of coenzyme Q(10) on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity
title_full Effects of coenzyme Q(10) on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity
title_fullStr Effects of coenzyme Q(10) on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity
title_full_unstemmed Effects of coenzyme Q(10) on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity
title_short Effects of coenzyme Q(10) on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity
title_sort effects of coenzyme q(10) on the antioxidant system in sd rats exposed to lipopolysaccharide-induced toxicity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385279/
https://www.ncbi.nlm.nih.gov/pubmed/28400836
http://dx.doi.org/10.5625/lar.2017.33.1.24
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