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Effects of coenzyme Q(10) on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity
The study was performed to see the effects of coenzyme Q(10) (CoQ(10)) on blood biochemical components and hepatic antioxidant system in rats exposed to lipopolysaccharide (LPS)-induced toxicity. A total of 24 rats were allocated to four groups: control (CON), 100 mg/kg BW of LPS (LPS), 100 mg of Co...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Association for Laboratory Animal Science
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385279/ https://www.ncbi.nlm.nih.gov/pubmed/28400836 http://dx.doi.org/10.5625/lar.2017.33.1.24 |
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author | Song, Min-Hae Kim, Ha-Na Lim, Yong Jang, In-Surk |
author_facet | Song, Min-Hae Kim, Ha-Na Lim, Yong Jang, In-Surk |
author_sort | Song, Min-Hae |
collection | PubMed |
description | The study was performed to see the effects of coenzyme Q(10) (CoQ(10)) on blood biochemical components and hepatic antioxidant system in rats exposed to lipopolysaccharide (LPS)-induced toxicity. A total of 24 rats were allocated to four groups: control (CON), 100 mg/kg BW of LPS (LPS), 100 mg of CoQ(10)/kg BW with LPS (LCQI) and 300 mg of CoQ(10)/kg BW with LPS (LCQII). The LPS and LCQI groups showed a significant (P<0.05) increase in the relative spleen weight compared with the CON group without affecting body and liver weights. The blood alanine aminotransferase (ALT) level in the LPS group was significantly (P<0.05) greater than that in the CON group, while supplementation with 100 or 300 mg CoQ(10) to rats injected with LPS normalized the ALT level in the CON group. In antioxidant systems, the LPS group showed a significantly (P<0.05) higher mRNA and activity of superoxide dismutase (SOD) than the CON group. The supplementation with CoQ(10) to the LPS-treated group normalized the level of SOD, which was comparable to the level of the CON group. Both the mRNA expression and activity of glutathione peroxidase in the LCQI and LCQII groups were higher (P<0.05) than that of the LPS group. However, administration of LPS or CoQ(10) unaffected the level of catalase and total antioxidant power. The level of lipid peroxidation in the LCQII group was lower (P<0.05) than that in the LPS group. In conclusion, CoQ(10) exerted its favorable effect against liver damage by modulation of antioxidant enzymes in LPS treated rats. |
format | Online Article Text |
id | pubmed-5385279 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Korean Association for Laboratory Animal Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-53852792017-04-11 Effects of coenzyme Q(10) on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity Song, Min-Hae Kim, Ha-Na Lim, Yong Jang, In-Surk Lab Anim Res Original Article The study was performed to see the effects of coenzyme Q(10) (CoQ(10)) on blood biochemical components and hepatic antioxidant system in rats exposed to lipopolysaccharide (LPS)-induced toxicity. A total of 24 rats were allocated to four groups: control (CON), 100 mg/kg BW of LPS (LPS), 100 mg of CoQ(10)/kg BW with LPS (LCQI) and 300 mg of CoQ(10)/kg BW with LPS (LCQII). The LPS and LCQI groups showed a significant (P<0.05) increase in the relative spleen weight compared with the CON group without affecting body and liver weights. The blood alanine aminotransferase (ALT) level in the LPS group was significantly (P<0.05) greater than that in the CON group, while supplementation with 100 or 300 mg CoQ(10) to rats injected with LPS normalized the ALT level in the CON group. In antioxidant systems, the LPS group showed a significantly (P<0.05) higher mRNA and activity of superoxide dismutase (SOD) than the CON group. The supplementation with CoQ(10) to the LPS-treated group normalized the level of SOD, which was comparable to the level of the CON group. Both the mRNA expression and activity of glutathione peroxidase in the LCQI and LCQII groups were higher (P<0.05) than that of the LPS group. However, administration of LPS or CoQ(10) unaffected the level of catalase and total antioxidant power. The level of lipid peroxidation in the LCQII group was lower (P<0.05) than that in the LPS group. In conclusion, CoQ(10) exerted its favorable effect against liver damage by modulation of antioxidant enzymes in LPS treated rats. Korean Association for Laboratory Animal Science 2017-03 2017-03-27 /pmc/articles/PMC5385279/ /pubmed/28400836 http://dx.doi.org/10.5625/lar.2017.33.1.24 Text en Copyright © 2017 Korean Association for Laboratory Animal Science http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Song, Min-Hae Kim, Ha-Na Lim, Yong Jang, In-Surk Effects of coenzyme Q(10) on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity |
title | Effects of coenzyme Q(10) on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity |
title_full | Effects of coenzyme Q(10) on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity |
title_fullStr | Effects of coenzyme Q(10) on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity |
title_full_unstemmed | Effects of coenzyme Q(10) on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity |
title_short | Effects of coenzyme Q(10) on the antioxidant system in SD rats exposed to lipopolysaccharide-induced toxicity |
title_sort | effects of coenzyme q(10) on the antioxidant system in sd rats exposed to lipopolysaccharide-induced toxicity |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385279/ https://www.ncbi.nlm.nih.gov/pubmed/28400836 http://dx.doi.org/10.5625/lar.2017.33.1.24 |
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