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HemoHIM, a herbal preparation, alleviates airway inflammation caused by cigarette smoke and lipopolysaccharide

HemoHIM, herbal preparation has designed for immune system recovery. We investigated the anti-inflammatory effect of HemoHIM on cigarette smoke (CS) and lipopolysaccharide (LPS) induced chronic obstructive pulmonary disease (COPD) mouse model. To induce COPD, C57BL/6 mice were exposed to CS for 1 h...

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Autores principales: Shin, Na-Rae, Kim, Sung-Ho, Ko, Je-Won, Park, Sung-Hyeuk, Lee, In-Chul, Ryu, Jung-Min, Kim, Jong-Choon, Shin, In-Sik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association for Laboratory Animal Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385281/
https://www.ncbi.nlm.nih.gov/pubmed/28400838
http://dx.doi.org/10.5625/lar.2017.33.1.40
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author Shin, Na-Rae
Kim, Sung-Ho
Ko, Je-Won
Park, Sung-Hyeuk
Lee, In-Chul
Ryu, Jung-Min
Kim, Jong-Choon
Shin, In-Sik
author_facet Shin, Na-Rae
Kim, Sung-Ho
Ko, Je-Won
Park, Sung-Hyeuk
Lee, In-Chul
Ryu, Jung-Min
Kim, Jong-Choon
Shin, In-Sik
author_sort Shin, Na-Rae
collection PubMed
description HemoHIM, herbal preparation has designed for immune system recovery. We investigated the anti-inflammatory effect of HemoHIM on cigarette smoke (CS) and lipopolysaccharide (LPS) induced chronic obstructive pulmonary disease (COPD) mouse model. To induce COPD, C57BL/6 mice were exposed to CS for 1 h per day (eight cigarettes per day) for 4 weeks and intranasally received LPS on day 26. HemoHIM was administrated to mice at a dose of 50 or 100 mg/kg 1h before CS exposure. HemoHIM reduced the inflammatory cell count and levels of tumor necrosis factor receptor (TNF)-α, interleukin (IL)-6 and IL-1β in the broncho-alveolar lavage fluid (BALF) induced by CS+LPS exposure. HemoHIM decreased the inflammatory cell infiltration in the airway and inhibited the expression of iNOS and MMP-9 and phosphorylation of Erk in lung tissue exposed to CS+LPS. In summary, our results indicate that HemoHIM inhibited a reduction in the lung inflammatory response on CS and LPS induced lung inflammation via the Erk pathway. Therefore, we suggest that HemoHIM has the potential to treat pulmonary inflammatory disease such as COPD.
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spelling pubmed-53852812017-04-11 HemoHIM, a herbal preparation, alleviates airway inflammation caused by cigarette smoke and lipopolysaccharide Shin, Na-Rae Kim, Sung-Ho Ko, Je-Won Park, Sung-Hyeuk Lee, In-Chul Ryu, Jung-Min Kim, Jong-Choon Shin, In-Sik Lab Anim Res Original Article HemoHIM, herbal preparation has designed for immune system recovery. We investigated the anti-inflammatory effect of HemoHIM on cigarette smoke (CS) and lipopolysaccharide (LPS) induced chronic obstructive pulmonary disease (COPD) mouse model. To induce COPD, C57BL/6 mice were exposed to CS for 1 h per day (eight cigarettes per day) for 4 weeks and intranasally received LPS on day 26. HemoHIM was administrated to mice at a dose of 50 or 100 mg/kg 1h before CS exposure. HemoHIM reduced the inflammatory cell count and levels of tumor necrosis factor receptor (TNF)-α, interleukin (IL)-6 and IL-1β in the broncho-alveolar lavage fluid (BALF) induced by CS+LPS exposure. HemoHIM decreased the inflammatory cell infiltration in the airway and inhibited the expression of iNOS and MMP-9 and phosphorylation of Erk in lung tissue exposed to CS+LPS. In summary, our results indicate that HemoHIM inhibited a reduction in the lung inflammatory response on CS and LPS induced lung inflammation via the Erk pathway. Therefore, we suggest that HemoHIM has the potential to treat pulmonary inflammatory disease such as COPD. Korean Association for Laboratory Animal Science 2017-03 2017-03-27 /pmc/articles/PMC5385281/ /pubmed/28400838 http://dx.doi.org/10.5625/lar.2017.33.1.40 Text en Copyright © 2017 Korean Association for Laboratory Animal Science http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Shin, Na-Rae
Kim, Sung-Ho
Ko, Je-Won
Park, Sung-Hyeuk
Lee, In-Chul
Ryu, Jung-Min
Kim, Jong-Choon
Shin, In-Sik
HemoHIM, a herbal preparation, alleviates airway inflammation caused by cigarette smoke and lipopolysaccharide
title HemoHIM, a herbal preparation, alleviates airway inflammation caused by cigarette smoke and lipopolysaccharide
title_full HemoHIM, a herbal preparation, alleviates airway inflammation caused by cigarette smoke and lipopolysaccharide
title_fullStr HemoHIM, a herbal preparation, alleviates airway inflammation caused by cigarette smoke and lipopolysaccharide
title_full_unstemmed HemoHIM, a herbal preparation, alleviates airway inflammation caused by cigarette smoke and lipopolysaccharide
title_short HemoHIM, a herbal preparation, alleviates airway inflammation caused by cigarette smoke and lipopolysaccharide
title_sort hemohim, a herbal preparation, alleviates airway inflammation caused by cigarette smoke and lipopolysaccharide
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385281/
https://www.ncbi.nlm.nih.gov/pubmed/28400838
http://dx.doi.org/10.5625/lar.2017.33.1.40
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