Glial Cell Line-Derived Neurotrophic Factor Gene Delivery in Parkinson's Disease: A Delicate Balance between Neuroprotection, Trophic Effects, and Unwanted Compensatory Mechanisms

Glial cell line-derived neurotrophic factor (GDNF) and Neurturin (NRTN) bind to a receptor complex consisting of a member of the GDNF family receptor (GFR)-α and the Ret tyrosine kinase. Both factors were shown to protect nigro-striatal dopaminergic neurons and reduce motor symptoms when applied ter...

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Detalles Bibliográficos
Autores principales: Tenenbaum, Liliane, Humbert-Claude, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385337/
https://www.ncbi.nlm.nih.gov/pubmed/28442998
http://dx.doi.org/10.3389/fnana.2017.00029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385337/
https://www.ncbi.nlm.nih.gov/pubmed/28442998
http://dx.doi.org/10.3389/fnana.2017.00029

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