Cargando…

Complementary Modular Microcircuits of the Rat Medial Entorhinal Cortex

The parahippocampal region is organized into different areas, with the medial entorhinal cortex (MEC), presubiculum and parasubiculum prominent in spatial memory. Here, we also describe a region at the extremity of the MEC and bordering the subicular complex, the medial-most part of the entorhinal c...

Descripción completa

Detalles Bibliográficos
Autores principales: Ray, Saikat, Burgalossi, Andrea, Brecht, Michael, Naumann, Robert K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385340/
https://www.ncbi.nlm.nih.gov/pubmed/28443003
http://dx.doi.org/10.3389/fnsys.2017.00020
_version_ 1782520579862036480
author Ray, Saikat
Burgalossi, Andrea
Brecht, Michael
Naumann, Robert K.
author_facet Ray, Saikat
Burgalossi, Andrea
Brecht, Michael
Naumann, Robert K.
author_sort Ray, Saikat
collection PubMed
description The parahippocampal region is organized into different areas, with the medial entorhinal cortex (MEC), presubiculum and parasubiculum prominent in spatial memory. Here, we also describe a region at the extremity of the MEC and bordering the subicular complex, the medial-most part of the entorhinal cortex. While the subdivisions of hippocampus proper form more or less continuous cell sheets, the superficial layers of the parahippocampal region have a distinct modular architecture. We investigate the spatial distribution, laminar position, and putative connectivity of zinc-positive modules in layer 2 of the MEC of rats and relate them to the calbindin-positive patches previously described in the entorhinal cortex. We found that the zinc-positive modules are complementary to the previously described calbindin-positive patches. We also found that inputs from the presubiculum are directed toward the zinc-positive modules while the calbindin-positive patches received inputs from the parasubiculum. Notably, the dendrites of neurons from layers 3 and 5, positive for Purkinje Cell Protein 4 expression, overlap with the zinc modules. Our data thus indicate that these two complementary modular systems, the calbindin patches and zinc modules, are part of parallel information streams in the hippocampal formation.
format Online
Article
Text
id pubmed-5385340
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-53853402017-04-25 Complementary Modular Microcircuits of the Rat Medial Entorhinal Cortex Ray, Saikat Burgalossi, Andrea Brecht, Michael Naumann, Robert K. Front Syst Neurosci Neuroscience The parahippocampal region is organized into different areas, with the medial entorhinal cortex (MEC), presubiculum and parasubiculum prominent in spatial memory. Here, we also describe a region at the extremity of the MEC and bordering the subicular complex, the medial-most part of the entorhinal cortex. While the subdivisions of hippocampus proper form more or less continuous cell sheets, the superficial layers of the parahippocampal region have a distinct modular architecture. We investigate the spatial distribution, laminar position, and putative connectivity of zinc-positive modules in layer 2 of the MEC of rats and relate them to the calbindin-positive patches previously described in the entorhinal cortex. We found that the zinc-positive modules are complementary to the previously described calbindin-positive patches. We also found that inputs from the presubiculum are directed toward the zinc-positive modules while the calbindin-positive patches received inputs from the parasubiculum. Notably, the dendrites of neurons from layers 3 and 5, positive for Purkinje Cell Protein 4 expression, overlap with the zinc modules. Our data thus indicate that these two complementary modular systems, the calbindin patches and zinc modules, are part of parallel information streams in the hippocampal formation. Frontiers Media S.A. 2017-04-10 /pmc/articles/PMC5385340/ /pubmed/28443003 http://dx.doi.org/10.3389/fnsys.2017.00020 Text en Copyright © 2017 Ray, Burgalossi, Brecht and Naumann. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Ray, Saikat
Burgalossi, Andrea
Brecht, Michael
Naumann, Robert K.
Complementary Modular Microcircuits of the Rat Medial Entorhinal Cortex
title Complementary Modular Microcircuits of the Rat Medial Entorhinal Cortex
title_full Complementary Modular Microcircuits of the Rat Medial Entorhinal Cortex
title_fullStr Complementary Modular Microcircuits of the Rat Medial Entorhinal Cortex
title_full_unstemmed Complementary Modular Microcircuits of the Rat Medial Entorhinal Cortex
title_short Complementary Modular Microcircuits of the Rat Medial Entorhinal Cortex
title_sort complementary modular microcircuits of the rat medial entorhinal cortex
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385340/
https://www.ncbi.nlm.nih.gov/pubmed/28443003
http://dx.doi.org/10.3389/fnsys.2017.00020
work_keys_str_mv AT raysaikat complementarymodularmicrocircuitsoftheratmedialentorhinalcortex
AT burgalossiandrea complementarymodularmicrocircuitsoftheratmedialentorhinalcortex
AT brechtmichael complementarymodularmicrocircuitsoftheratmedialentorhinalcortex
AT naumannrobertk complementarymodularmicrocircuitsoftheratmedialentorhinalcortex