Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data

Next-generation sequencing (NGS) has been applied successfully to the field of therapeutic antibody discovery, often outperforming conventional screening campaigns which tend to identify only the more abundant selective antibody sequences. We used NGS to mine the functional nanobody repertoire from...

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Detalles Bibliográficos
Autores principales: Deschaght, Pieter, Vintém, Ana Paula, Logghe, Marc, Conde, Miguel, Felix, David, Mensink, Rob, Gonçalves, Juliana, Audiens, Jorn, Bruynooghe, Yanik, Figueiredo, Rita, Ramos, Diana, Tanghe, Robbe, Teixeira, Daniela, Van de Ven, Liesbeth, Stortelers, Catelijne, Dombrecht, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385344/
https://www.ncbi.nlm.nih.gov/pubmed/28443097
http://dx.doi.org/10.3389/fimmu.2017.00420

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