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High-grade Gliomas Exhibit Higher Peritumoral Fractional Anisotropy and Lower Mean Diffusivity than Intracranial Metastases

Differentiating high-grade gliomas and intracranial metastases through non-invasive imaging has been challenging. Here, we retrospectively compared both intratumoral and peritumoral fractional anisotropy (FA), mean diffusivity (MD), and fluid-attenuated inversion recovery (FLAIR) measurements betwee...

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Autores principales: Holly, Kevin S., Barker, Benjamin J., Murcia, Derrick, Bennett, Rebekah, Kalakoti, Piyush, Ledbetter, Christina, Gonzalez-Toledo, Eduardo, Nanda, Anil, Sun, Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385351/
https://www.ncbi.nlm.nih.gov/pubmed/28443285
http://dx.doi.org/10.3389/fsurg.2017.00018
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author Holly, Kevin S.
Barker, Benjamin J.
Murcia, Derrick
Bennett, Rebekah
Kalakoti, Piyush
Ledbetter, Christina
Gonzalez-Toledo, Eduardo
Nanda, Anil
Sun, Hai
author_facet Holly, Kevin S.
Barker, Benjamin J.
Murcia, Derrick
Bennett, Rebekah
Kalakoti, Piyush
Ledbetter, Christina
Gonzalez-Toledo, Eduardo
Nanda, Anil
Sun, Hai
author_sort Holly, Kevin S.
collection PubMed
description Differentiating high-grade gliomas and intracranial metastases through non-invasive imaging has been challenging. Here, we retrospectively compared both intratumoral and peritumoral fractional anisotropy (FA), mean diffusivity (MD), and fluid-attenuated inversion recovery (FLAIR) measurements between high-grade gliomas and metastases. Two methods were utilized to select peritumoral region of interest (ROI). The first method utilized the manual placement of four ROIs adjacent to the lesion. The second method utilized a semiautomated and proprietary MATLAB script to generate an ROI encompassing the entire tumor. The average peritumoral FA, MD, and FLAIR values were determined within the ROIs for both methods. Forty patients with high-grade gliomas and 44 with metastases were enrolled in this study. Thirty-five patients with high-grade glioma and 30 patients with metastases had FLAIR images. There was no significant difference in age, gender, or race between the two patient groups. The high-grade gliomas had a significantly higher tumor-to-brain area ratio compared to the metastases. There were no differences in average intratumoral FA, MD, and FLAIR values between the two groups. Both the manual sample method and the semiautomated peritumoral ring method resulted in significantly higher peritumoral FA and significantly lower peritumoral MD in high-grade gliomas compared to metastases (p < 0.05). No significant difference was found in FLAIR values between the two groups peritumorally. Receiver operating curve analysis revealed FA to be a more sensitive and specific metric to differentiate high-grade gliomas and metastases than MD. The differences in the peritumoral FA and MD values between high-grade gliomas and metastases seemed due to the infiltration of glioma to the surrounding brain parenchyma.
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spelling pubmed-53853512017-04-25 High-grade Gliomas Exhibit Higher Peritumoral Fractional Anisotropy and Lower Mean Diffusivity than Intracranial Metastases Holly, Kevin S. Barker, Benjamin J. Murcia, Derrick Bennett, Rebekah Kalakoti, Piyush Ledbetter, Christina Gonzalez-Toledo, Eduardo Nanda, Anil Sun, Hai Front Surg Surgery Differentiating high-grade gliomas and intracranial metastases through non-invasive imaging has been challenging. Here, we retrospectively compared both intratumoral and peritumoral fractional anisotropy (FA), mean diffusivity (MD), and fluid-attenuated inversion recovery (FLAIR) measurements between high-grade gliomas and metastases. Two methods were utilized to select peritumoral region of interest (ROI). The first method utilized the manual placement of four ROIs adjacent to the lesion. The second method utilized a semiautomated and proprietary MATLAB script to generate an ROI encompassing the entire tumor. The average peritumoral FA, MD, and FLAIR values were determined within the ROIs for both methods. Forty patients with high-grade gliomas and 44 with metastases were enrolled in this study. Thirty-five patients with high-grade glioma and 30 patients with metastases had FLAIR images. There was no significant difference in age, gender, or race between the two patient groups. The high-grade gliomas had a significantly higher tumor-to-brain area ratio compared to the metastases. There were no differences in average intratumoral FA, MD, and FLAIR values between the two groups. Both the manual sample method and the semiautomated peritumoral ring method resulted in significantly higher peritumoral FA and significantly lower peritumoral MD in high-grade gliomas compared to metastases (p < 0.05). No significant difference was found in FLAIR values between the two groups peritumorally. Receiver operating curve analysis revealed FA to be a more sensitive and specific metric to differentiate high-grade gliomas and metastases than MD. The differences in the peritumoral FA and MD values between high-grade gliomas and metastases seemed due to the infiltration of glioma to the surrounding brain parenchyma. Frontiers Media S.A. 2017-04-10 /pmc/articles/PMC5385351/ /pubmed/28443285 http://dx.doi.org/10.3389/fsurg.2017.00018 Text en Copyright © 2017 Holly, Barker, Murcia, Bennett, Kalakoti, Ledbetter, Gonzalez-Toledo, Nanda and Sun. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Holly, Kevin S.
Barker, Benjamin J.
Murcia, Derrick
Bennett, Rebekah
Kalakoti, Piyush
Ledbetter, Christina
Gonzalez-Toledo, Eduardo
Nanda, Anil
Sun, Hai
High-grade Gliomas Exhibit Higher Peritumoral Fractional Anisotropy and Lower Mean Diffusivity than Intracranial Metastases
title High-grade Gliomas Exhibit Higher Peritumoral Fractional Anisotropy and Lower Mean Diffusivity than Intracranial Metastases
title_full High-grade Gliomas Exhibit Higher Peritumoral Fractional Anisotropy and Lower Mean Diffusivity than Intracranial Metastases
title_fullStr High-grade Gliomas Exhibit Higher Peritumoral Fractional Anisotropy and Lower Mean Diffusivity than Intracranial Metastases
title_full_unstemmed High-grade Gliomas Exhibit Higher Peritumoral Fractional Anisotropy and Lower Mean Diffusivity than Intracranial Metastases
title_short High-grade Gliomas Exhibit Higher Peritumoral Fractional Anisotropy and Lower Mean Diffusivity than Intracranial Metastases
title_sort high-grade gliomas exhibit higher peritumoral fractional anisotropy and lower mean diffusivity than intracranial metastases
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385351/
https://www.ncbi.nlm.nih.gov/pubmed/28443285
http://dx.doi.org/10.3389/fsurg.2017.00018
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