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Advanced pancreatic ductal adenocarcinoma - Complexities of treatment and emerging therapeutic options

Pancreatic ductal adenocarcinoma is a devastating disease with a poor prognosis regardless of stage. To date the mainstay of therapy for advanced disease has been chemotherapy with little incremental improvements in outcome. Despite extensive research investigating new treatment options the current...

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Autores principales: Diwakarla, Chandra, Hannan, Katherine, Hein, Nadine, Yip, Desmond
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385394/
https://www.ncbi.nlm.nih.gov/pubmed/28428707
http://dx.doi.org/10.3748/wjg.v23.i13.2276
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author Diwakarla, Chandra
Hannan, Katherine
Hein, Nadine
Yip, Desmond
author_facet Diwakarla, Chandra
Hannan, Katherine
Hein, Nadine
Yip, Desmond
author_sort Diwakarla, Chandra
collection PubMed
description Pancreatic ductal adenocarcinoma is a devastating disease with a poor prognosis regardless of stage. To date the mainstay of therapy for advanced disease has been chemotherapy with little incremental improvements in outcome. Despite extensive research investigating new treatment options the current practices continue to utilise fluorouracil or gemcitabine containing combinations. The need for novel therapeutic approaches is mandated by the ongoing poor survival rates associated with this disease. One such approach may include manipulation of ribosome biogenesis and the nucleolar stress response, which has recently been applied to haematological malignancies such as lymphoma and prostate cancer with promising results. This review will focus on the current therapeutic options for pancreatic ductal adenocarcinoma and the complexities associated with developing novel treatments, with a particular emphasis on the role of the nucleolus as a treatment strategy.
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spelling pubmed-53853942017-04-20 Advanced pancreatic ductal adenocarcinoma - Complexities of treatment and emerging therapeutic options Diwakarla, Chandra Hannan, Katherine Hein, Nadine Yip, Desmond World J Gastroenterol Review Pancreatic ductal adenocarcinoma is a devastating disease with a poor prognosis regardless of stage. To date the mainstay of therapy for advanced disease has been chemotherapy with little incremental improvements in outcome. Despite extensive research investigating new treatment options the current practices continue to utilise fluorouracil or gemcitabine containing combinations. The need for novel therapeutic approaches is mandated by the ongoing poor survival rates associated with this disease. One such approach may include manipulation of ribosome biogenesis and the nucleolar stress response, which has recently been applied to haematological malignancies such as lymphoma and prostate cancer with promising results. This review will focus on the current therapeutic options for pancreatic ductal adenocarcinoma and the complexities associated with developing novel treatments, with a particular emphasis on the role of the nucleolus as a treatment strategy. Baishideng Publishing Group Inc 2017-04-07 2017-04-07 /pmc/articles/PMC5385394/ /pubmed/28428707 http://dx.doi.org/10.3748/wjg.v23.i13.2276 Text en ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Diwakarla, Chandra
Hannan, Katherine
Hein, Nadine
Yip, Desmond
Advanced pancreatic ductal adenocarcinoma - Complexities of treatment and emerging therapeutic options
title Advanced pancreatic ductal adenocarcinoma - Complexities of treatment and emerging therapeutic options
title_full Advanced pancreatic ductal adenocarcinoma - Complexities of treatment and emerging therapeutic options
title_fullStr Advanced pancreatic ductal adenocarcinoma - Complexities of treatment and emerging therapeutic options
title_full_unstemmed Advanced pancreatic ductal adenocarcinoma - Complexities of treatment and emerging therapeutic options
title_short Advanced pancreatic ductal adenocarcinoma - Complexities of treatment and emerging therapeutic options
title_sort advanced pancreatic ductal adenocarcinoma - complexities of treatment and emerging therapeutic options
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385394/
https://www.ncbi.nlm.nih.gov/pubmed/28428707
http://dx.doi.org/10.3748/wjg.v23.i13.2276
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