Immunotherapies in sarcoma: Updates and future perspectives

Sarcomas are malignant tumors that are characterized by a wide diversity of subtypes with various cytogenetic profiles. Despite major treatment breakthroughs, standard treatment modalities combining chemotherapy, radiotherapy, and surgery failed to improve overall survival. Therefore, high expectati...

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Detalles Bibliográficos
Autores principales: Ghosn, Marwan, El Rassy, Elie, Kourie, Hampig Raphael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2017
Materias:
Minireviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385435/
https://www.ncbi.nlm.nih.gov/pubmed/28439495
http://dx.doi.org/10.5306/wjco.v8.i2.145
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author Ghosn, Marwan
El Rassy, Elie
Kourie, Hampig Raphael
author_facet Ghosn, Marwan
El Rassy, Elie
Kourie, Hampig Raphael
author_sort Ghosn, Marwan
collection PubMed
description Sarcomas are malignant tumors that are characterized by a wide diversity of subtypes with various cytogenetic profiles. Despite major treatment breakthroughs, standard treatment modalities combining chemotherapy, radiotherapy, and surgery failed to improve overall survival. Therefore, high expectations are foreseen with immunotherapy upon its maturation and better understanding of its mechanism of action. This paper presents a targeted review of the published data and ongoing clinical trials in immunotherapies of sarcomas, mainly adoptive cell therapies, cancer vaccines and immune checkpoint inhibitors.
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spelling pubmed-53854352017-04-24 Immunotherapies in sarcoma: Updates and future perspectives Ghosn, Marwan El Rassy, Elie Kourie, Hampig Raphael World J Clin Oncol Minireviews Sarcomas are malignant tumors that are characterized by a wide diversity of subtypes with various cytogenetic profiles. Despite major treatment breakthroughs, standard treatment modalities combining chemotherapy, radiotherapy, and surgery failed to improve overall survival. Therefore, high expectations are foreseen with immunotherapy upon its maturation and better understanding of its mechanism of action. This paper presents a targeted review of the published data and ongoing clinical trials in immunotherapies of sarcomas, mainly adoptive cell therapies, cancer vaccines and immune checkpoint inhibitors. Baishideng Publishing Group Inc 2017-04-10 2017-04-10 /pmc/articles/PMC5385435/ /pubmed/28439495 http://dx.doi.org/10.5306/wjco.v8.i2.145 Text en ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Minireviews
Ghosn, Marwan
El Rassy, Elie
Kourie, Hampig Raphael
Immunotherapies in sarcoma: Updates and future perspectives
title Immunotherapies in sarcoma: Updates and future perspectives
title_full Immunotherapies in sarcoma: Updates and future perspectives
title_fullStr Immunotherapies in sarcoma: Updates and future perspectives
title_full_unstemmed Immunotherapies in sarcoma: Updates and future perspectives
title_short Immunotherapies in sarcoma: Updates and future perspectives
title_sort immunotherapies in sarcoma: updates and future perspectives
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385435/
https://www.ncbi.nlm.nih.gov/pubmed/28439495
http://dx.doi.org/10.5306/wjco.v8.i2.145
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AT kouriehampigraphael immunotherapiesinsarcomaupdatesandfutureperspectives

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