Engineered Split-TET2 Enzyme for Inducible Epigenetic Remodeling

[Image: see text] The Ten-eleven translocation (TET) family of 5-methylcytosine (5mC) dioxygenases catalyze the conversion of 5mC into 5-hydroxymethylcytosine (5hmC) and further oxidized species to promote active DNA demethylation. Here we engineered a split-TET2 enzyme to enable temporal control of...

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Detalles Bibliográficos
Autores principales: Lee, Minjung, Li, Jia, Liang, Yi, Ma, Guolin, Zhang, Jixiang, He, Lian, Liu, Yuliang, Li, Qian, Li, Minyong, Sun, Deqiang, Zhou, Yubin, Huang, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385525/
https://www.ncbi.nlm.nih.gov/pubmed/28294608
http://dx.doi.org/10.1021/jacs.7b01459

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