Mechanistic insights into ectodomain shedding: susceptibility of CADM1 adhesion molecule is determined by alternative splicing and O-glycosylation

Ectodomain shedding (shedding) is a post-translational modification, which liberates the extracellular domain of membrane proteins through juxtamembrane processing executed mainly by the ADAM (a disintegrin and metalloprotease) family of metalloproteases. Because shedding alters characteristics of c...

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Detalles Bibliográficos
Autores principales: Shirakabe, Kyoko, Omura, Takuya, Shibagaki, Yoshio, Mihara, Emiko, Homma, Keiichi, Kato, Yukinari, Yoshimura, Akihiko, Murakami, Yoshinori, Takagi, Junichi, Hattori, Seisuke, Ogawa, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385562/
https://www.ncbi.nlm.nih.gov/pubmed/28393893
http://dx.doi.org/10.1038/srep46174

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