Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration

Autophagosomes primarily mediate turnover of cytoplasmic proteins or organelles to provide nutrients and eliminate damaged proteins. In neurons, autophagosomes form in distal axons and are trafficked retrogradely to fuse with lysosomes in the soma. Although defective neuronal autophagy is associated...

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Detalles Bibliográficos
Autores principales: Kononenko, Natalia L., Claßen, Gala A., Kuijpers, Marijn, Puchkov, Dmytro, Maritzen, Tanja, Tempes, Aleksandra, Malik, Anna R., Skalecka, Agnieszka, Bera, Sujoy, Jaworski, Jacek, Haucke, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385568/
https://www.ncbi.nlm.nih.gov/pubmed/28387218
http://dx.doi.org/10.1038/ncomms14819

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385568/
https://www.ncbi.nlm.nih.gov/pubmed/28387218
http://dx.doi.org/10.1038/ncomms14819

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