Targeted activation of diverse CRISPR-Cas systems for mammalian genome editing via proximal CRISPR targeting

Bacterial CRISPR–Cas systems comprise diverse effector endonucleases with different targeting ranges, specificities and enzymatic properties, but many of them are inactive in mammalian cells and are thus precluded from genome-editing applications. Here we show that the type II-B FnCas9 from Francise...

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Detalles Bibliográficos
Autores principales: Chen, Fuqiang, Ding, Xiao, Feng, Yongmei, Seebeck, Timothy, Jiang, Yanfang, Davis, Gregory D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385574/
https://www.ncbi.nlm.nih.gov/pubmed/28387220
http://dx.doi.org/10.1038/ncomms14958

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