Blocking the recruitment of naive CD4(+) T cells reverses immunosuppression in breast cancer

The origin of tumor-infiltrating Tregs, critical mediators of tumor immunosuppression, is unclear. Here, we show that tumor-infiltrating naive CD4(+) T cells and Tregs in human breast cancer have overlapping TCR repertoires, while hardly overlap with circulating Tregs, suggesting that intratumoral T...

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Detalles Bibliográficos
Autores principales: Su, Shicheng, Liao, Jianyou, Liu, Jiang, Huang, Di, He, Chonghua, Chen, Fei, Yang, LinBing, Wu, Wei, Chen, Jianing, Lin, Ling, Zeng, Yunjie, Ouyang, Nengtai, Cui, Xiuying, Yao, Herui, Su, Fengxi, Huang, Jian-dong, Lieberman, Judy, Liu, Qiang, Song, Erwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385617/
https://www.ncbi.nlm.nih.gov/pubmed/28290464
http://dx.doi.org/10.1038/cr.2017.34

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