Drimane Sesquiterpenoids and Isochromone Derivative from the Endophytic Fungus Pestalotiopsis sp. M-23

ABSTRACT: Three new drimane sesquiterpenoids (1–3) together with the known 2α-hydroxyisodrimeninol (4), and a new isochromone derivative (5), were obtained from the solid cultures of fungal strain Pestalotiopsis sp. M-23, an endophytic fungus isolated from the leaves of Leucosceptrum canum (Labiatae...

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Autores principales: Kuang, Ce, Jing, Shu-Xi, Liu, Yan, Luo, Shi-Hong, Li, Sheng-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385658/
https://www.ncbi.nlm.nih.gov/pubmed/27038619
http://dx.doi.org/10.1007/s13659-016-0094-6
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author Kuang, Ce
Jing, Shu-Xi
Liu, Yan
Luo, Shi-Hong
Li, Sheng-Hong
author_facet Kuang, Ce
Jing, Shu-Xi
Liu, Yan
Luo, Shi-Hong
Li, Sheng-Hong
author_sort Kuang, Ce
collection PubMed
description ABSTRACT: Three new drimane sesquiterpenoids (1–3) together with the known 2α-hydroxyisodrimeninol (4), and a new isochromone derivative (5), were obtained from the solid cultures of fungal strain Pestalotiopsis sp. M-23, an endophytic fungus isolated from the leaves of Leucosceptrum canum (Labiatae). Their structures were determined by comprehensive 1D and 2D NMR, and MS analyses. The metabolites were evaluated for their antibacterial activities, and compound 3 showed weak inhibitory activity against Bacillus subtilis. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-016-0094-6) contains supplementary material, which is available to authorized users.
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spelling pubmed-53856582017-04-24 Drimane Sesquiterpenoids and Isochromone Derivative from the Endophytic Fungus Pestalotiopsis sp. M-23 Kuang, Ce Jing, Shu-Xi Liu, Yan Luo, Shi-Hong Li, Sheng-Hong Nat Prod Bioprospect Original Article ABSTRACT: Three new drimane sesquiterpenoids (1–3) together with the known 2α-hydroxyisodrimeninol (4), and a new isochromone derivative (5), were obtained from the solid cultures of fungal strain Pestalotiopsis sp. M-23, an endophytic fungus isolated from the leaves of Leucosceptrum canum (Labiatae). Their structures were determined by comprehensive 1D and 2D NMR, and MS analyses. The metabolites were evaluated for their antibacterial activities, and compound 3 showed weak inhibitory activity against Bacillus subtilis. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-016-0094-6) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2016-04-02 /pmc/articles/PMC5385658/ /pubmed/27038619 http://dx.doi.org/10.1007/s13659-016-0094-6 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Kuang, Ce
Jing, Shu-Xi
Liu, Yan
Luo, Shi-Hong
Li, Sheng-Hong
Drimane Sesquiterpenoids and Isochromone Derivative from the Endophytic Fungus Pestalotiopsis sp. M-23
title Drimane Sesquiterpenoids and Isochromone Derivative from the Endophytic Fungus Pestalotiopsis sp. M-23
title_full Drimane Sesquiterpenoids and Isochromone Derivative from the Endophytic Fungus Pestalotiopsis sp. M-23
title_fullStr Drimane Sesquiterpenoids and Isochromone Derivative from the Endophytic Fungus Pestalotiopsis sp. M-23
title_full_unstemmed Drimane Sesquiterpenoids and Isochromone Derivative from the Endophytic Fungus Pestalotiopsis sp. M-23
title_short Drimane Sesquiterpenoids and Isochromone Derivative from the Endophytic Fungus Pestalotiopsis sp. M-23
title_sort drimane sesquiterpenoids and isochromone derivative from the endophytic fungus pestalotiopsis sp. m-23
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385658/
https://www.ncbi.nlm.nih.gov/pubmed/27038619
http://dx.doi.org/10.1007/s13659-016-0094-6
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