Neolignans from Selaginella moellendorffii

ABSTRACT: Two new neolignans selaginellol (1) and selaginellol 4′-O-β-d-glucopyranoside (2), together with seven known compounds (3–9), were isolated from the whole plant of Selaginella moellendorffii. The structures of the new isolates were determined through spectroscopic data analysis. Compounds 1–9, as well as compounds 10–18 previously isolated from the species, were measured for the activity against platelet aggregation induced by ADP or collagen. Three neoligans (8, 11, and 12), one flavanone (14), and one alkaloid (16) showed inhibitory activity against ADP- or collagen-induced platelet aggregation as compared with tirofiban. The dihydrobenzofuran neolignans (8, 11, and 12) are more potent than the benzofuran neolignan (13) and other types of neolignans (1–7). Glucosidation of the dihydrobenzofuran neolignans (11 and 12) is helpful for the activity. GRAPHICAL ABSTRACT: Two new neolignans selaginellol (1) and selaginellol 4′-O-β-d-glucopyranoside (2) were isolated from the whole plant of Selaginella moellendorffii. Several compounds from this plant showed the activity against platelet aggregation induced by ADP or collagen. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-016-0095-5) contains supplementary material, which is available to authorized users.