Cargando…
HOPS catalyzes the interdependent assembly of each vacuolar SNARE into a SNARE complex
Rab GTPases, their effectors, SNAREs of the R, Qa, Qb, and Qc families, and SM SNARE-binding proteins catalyze intracellular membrane fusion. At the vacuole/lysosome, they are integrated by the homotypic fusion and vacuole protein sorting (HOPS) complex. Two HOPS subunits bind vacuolar Rabs for teth...
Autores principales: | Orr, Amy, Song, Hongki, Rusin, Scott F., Kettenbach, Arminja N., Wickner, William |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385945/ https://www.ncbi.nlm.nih.gov/pubmed/28148647 http://dx.doi.org/10.1091/mbc.E16-10-0743 |
Ejemplares similares
-
Asymmetric Rab activation of vacuolar HOPS to catalyze SNARE complex assembly
por: Torng, Thomas, et al.
Publicado: (2020) -
HOPS recognizes each SNARE, assembling ternary trans-complexes for rapid fusion upon engagement with the 4th SNARE
por: Song, Hongki, et al.
Publicado: (2020) -
Yeast vacuolar HOPS, regulated by its kinase, exploits affinities for acidic lipids and Rab:GTP for membrane binding and to catalyze tethering and fusion
por: Orr, Amy, et al.
Publicado: (2015) -
The tethering complex HOPS catalyzes assembly of the soluble SNARE Vam7 into fusogenic trans-SNARE complexes
por: Zick, Michael, et al.
Publicado: (2013) -
A short region upstream of the yeast vacuolar Qa-SNARE heptad-repeats promotes membrane fusion through enhanced SNARE complex assembly
por: Song, Hongki, et al.
Publicado: (2017)