Cargando…

When transporters fail to be transported: how to rescue folding-deficient SLC6 transporters

The human dopamine transporter (hDAT) belongs to the solute carrier 6 (SLC6) gene family. Point mutations in hDAT (SLC6A3) have been linked to a syndrome of dopamine transporter deficiency or infantile dystonia/parkinsonism. The mutations impair DAT folding, causing retention of variant DATs in the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sucic, Sonja, Kasture, Ameya, Mazhar Asjad, H. M., Kern, Carina, El-Kasaby, Ali, Freissmuth, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386142/ https://www.ncbi.nlm.nih.gov/pubmed/28405636

Ejemplares similares

Pharmacochaperoning in a Drosophila model system rescues human dopamine transporter variants associated with infantile/juvenile parkinsonism
por: Asjad, H. M. Mazhar, et al.
Publicado: (2017)

Functional Rescue of a Misfolded Drosophila melanogaster Dopamine Transporter Mutant Associated with a Sleepless Phenotype by Pharmacological Chaperones
por: Kasture, Ameya, et al.
Publicado: (2016)

Relax, Cool Down and Scaffold: How to Restore Surface Expression of Folding-Deficient Mutant GPCRs and SLC6 Transporters
por: Asjad, H.M. Mazhar, et al.
Publicado: (2017)

Tropane-Based Ibogaine Analog Rescues Folding-Deficient Serotonin and Dopamine Transporters
por: Bhat, Shreyas, et al.
Publicado: (2020)

How does the carboxyl terminus assist folding and ER export of the serotonin transporter?
por: El-Kasaby, Ali, et al.
Publicado: (2012)

The N Terminus Specifies the Switch between Transport Modes of the Human Serotonin Transporter
por: Kern, Carina, et al.
Publicado: (2017)

Functional and Biochemical Consequences of Disease Variants in Neurotransmitter Transporters: A Special Emphasis on Folding and Trafficking Deficits
por: Bhat, Shreyas, et al.
Publicado: (2021)

A mechanism of uncompetitive inhibition of the serotonin transporter
por: Bhat, Shreyas, et al.
Publicado: (2023)

The Creatine Transporter Unfolded: A Knotty Premise in the Cerebral Creatine Deficiency Syndrome
por: Farr, Clemens V., et al.
Publicado: (2020)

Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates
por: Bhat, Shreyas, et al.
Publicado: (2017)

A Cytosolic Relay of Heat Shock Proteins HSP70-1A and HSP90β Monitors the Folding Trajectory of the Serotonin Transporter
por: El-Kasaby, Ali, et al.
Publicado: (2014)

A Salt Bridge Linking the First Intracellular Loop with the C Terminus Facilitates the Folding of the Serotonin Transporter
por: Koban, Florian, et al.
Publicado: (2015)

The role of the carboxyl terminus in folding of the serotonin transporter
por: El-Kasaby, Ali, et al.
Publicado: (2010)

The N-terminus acts as a lever to support amphetamine-induced substrate efflux by the serotonin transporter
por: Sucic, Sonja, et al.
Publicado: (2012)

Drosophila melanogaster as a model for unraveling unique molecular features of epilepsy elicited by human GABA transporter 1 variants
por: Kasture, Ameya S., et al.
Publicado: (2023)

Molecular and Clinical Repercussions of GABA Transporter 1 Variants Gone Amiss: Links to Epilepsy and Developmental Spectrum Disorders
por: Fischer, Florian P., et al.
Publicado: (2022)

Concentrative ER export of the serotonin transporter relies exclusively on an interaction with Sec24C
por: Sucic, Sonja, et al.
Publicado: (2010)

Cooperative Binding of Substrate and Ions Drives Forward Cycling of the Human Creatine Transporter-1
por: Farr, Clemens V., et al.
Publicado: (2022)

Rescue of Misfolded Organic Cation Transporter 3 Variants
por: Angenoorth, Thomas J. F., et al.
Publicado: (2022)

Mutations in the Carboxyl-terminal SEC24 Binding Motif of the Serotonin Transporter Impair Folding of the Transporter
por: El-Kasaby, Ali, et al.
Publicado: (2010)

The Serotonin Transporter Is an Exclusive Client of the Coat Protein Complex II (COPII) Component SEC24C
por: Sucic, Sonja, et al.
Publicado: (2011)

Defining the blanks – Pharmacochaperoning of SLC6 transporters and ABC transporters()
por: Chiba, Peter, et al.
Publicado: (2014)

Big Lessons from Tiny Flies: Drosophila melanogaster as a Model to Explore Dysfunction of Dopaminergic and Serotonergic Neurotransmitter Systems
por: Kasture, Ameya Sanjay, et al.
Publicado: (2018)

Truncations in the amino terminus reveal a region key to supporting amphetamine-induced efflux by the human serotonin transporter
por: Sucic, Sonja, et al.
Publicado: (2011)

Switching the Clientele: A LYSINE RESIDING IN THE C TERMINUS OF THE SEROTONIN TRANSPORTER SPECIFIES ITS PREFERENCE FOR THE COAT PROTEIN COMPLEX II COMPONENT SEC24C
por: Sucic, Sonja, et al.
Publicado: (2013)

Importance of the carboxyl terminus for folding and trafficking of the serotonin transporter
por: El-Kasaby, Ali, et al.
Publicado: (2009)

Calmodulin kinase II regulates amphetamine-induced reverse transport in dopamine and serotonin transporters
por: Steinkellner, Thomas, et al.
Publicado: (2012)

Constitutive Endocytosis of the Neuronal Glutamate Transporter Excitatory Amino Acid Transporter-3 Requires ARFGAP1
por: Saha, Kusumika, et al.
Publicado: (2021)

Trafficking of the amino acid transporter B(0,+) (SLC6A14) to the plasma membrane involves an exclusive interaction with SEC24C for its exit from the endoplasmic reticulum
por: Kovalchuk, Vasylyna, et al.
Publicado: (2018)

The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter
por: Sarker, Subhodeep, et al.
Publicado: (2010)

Neurosteroid Transport in the Brain: Role of ABC and SLC Transporters
por: Grube, Markus, et al.
Publicado: (2018)

Mutations in the amino-terminus impair amphetamine-induced efflux by inducing inward-facing conformations of the serotonin transporter
por: Sucic, Sonja, et al.
Publicado: (2009)

Standardized phytotherapic extracts rescue anomalous locomotion and electrophysiological responses of TDP-43 Drosophila melanogaster model of ALS
por: Maccioni, Riccardo, et al.
Publicado: (2018)

SLC6 transporter oligomerization
por: Jayaraman, Kumaresan, et al.
Publicado: (2020)

Characterising the interaction between the COPII component SEC24C and the human serotonin transporter
por: Koban, Florian, et al.
Publicado: (2011)

A comparison of the transport kinetics of glycine transporter 1 and glycine transporter 2
por: Erdem, Fatma Asli, et al.
Publicado: (2019)

Determinants of coupled transport and uncoupled current by the electrogenic SLC26 transporters
por: Ohana, Ehud, et al.
Publicado: (2011)

Axonal Transport Defect in Gigaxonin Deficiency Rescued by Tubastatin A
por: Nath, Banshi, et al.
Publicado: (2023)

Descriptors of Secondary Active Transporter Function and How They Relate to Partial Reactions in the Transport Cycle
por: Schicker, Klaus, et al.
Publicado: (2021)

Folding correction of ABC‐transporter ABCB1 by pharmacological chaperones: a mechanistic concept
por: Spork, Matthias, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_nqt95vaklfb5dn3l3501d60a8k