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Toll-like receptor 4 contributes to the inhibitory effect of morphine on colonic motility in vitro and in vivo
Opioids rank among the most potent analgesic drugs but gastrointestinal side effects, especially constipation, limit their therapeutic utility. The adverse effects of opioids have been attributed to stimulation of opioid receptors, but emerging evidence suggests that opioids interact with the innate...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386182/ https://www.ncbi.nlm.nih.gov/pubmed/25962524 http://dx.doi.org/10.1038/srep09499 |