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Genomic ancestry and ethnoracial self-classification based on 5,871 community-dwelling Brazilians (The Epigen Initiative)
Brazil never had segregation laws defining membership of an ethnoracial group. Thus, the composition of the Brazilian population is mixed, and its ethnoracial classification is complex. Previous studies showed conflicting results on the correlation between genome ancestry and ethnoracial classificat...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386196/ https://www.ncbi.nlm.nih.gov/pubmed/25913126 http://dx.doi.org/10.1038/srep09812 |
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author | Lima-Costa, M. Fernanda Rodrigues, Laura C. Barreto, Maurício L. Gouveia, Mateus Horta, Bernardo L. Mambrini, Juliana Kehdy, Fernanda S. G. Pereira, Alexandre Rodrigues-Soares, Fernanda Victora, Cesar G. Tarazona-Santos, Eduardo |
author_facet | Lima-Costa, M. Fernanda Rodrigues, Laura C. Barreto, Maurício L. Gouveia, Mateus Horta, Bernardo L. Mambrini, Juliana Kehdy, Fernanda S. G. Pereira, Alexandre Rodrigues-Soares, Fernanda Victora, Cesar G. Tarazona-Santos, Eduardo |
author_sort | Lima-Costa, M. Fernanda |
collection | PubMed |
description | Brazil never had segregation laws defining membership of an ethnoracial group. Thus, the composition of the Brazilian population is mixed, and its ethnoracial classification is complex. Previous studies showed conflicting results on the correlation between genome ancestry and ethnoracial classification in Brazilians. We used 370,539 Single Nucleotide Polymorphisms to quantify this correlation in 5,851 community-dwelling individuals in the South (Pelotas), Southeast (Bambui) and Northeast (Salvador) Brazil. European ancestry was predominant in Pelotas and Bambui (median = 85.3% and 83.8%, respectively). African ancestry was highest in Salvador (median = 50.5%). The strength of the association between the phenotype and median proportion of African ancestry varied largely across populations, with pseudo R(2) values of 0.50 in Pelotas, 0.22 in Bambui and 0.13 in Salvador. The continuous proportion of African genomic ancestry showed a significant S-shape positive association with self-reported Blacks in the three sites, and the reverse trend was found for self reported Whites, with most consistent classifications in the extremes of the high and low proportion of African ancestry. In self-classified Mixed individuals, the predicted probability of having African ancestry was bell-shaped. Our results support the view that ethnoracial self-classification is affected by both genome ancestry and non-biological factors. |
format | Online Article Text |
id | pubmed-5386196 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-53861962017-04-14 Genomic ancestry and ethnoracial self-classification based on 5,871 community-dwelling Brazilians (The Epigen Initiative) Lima-Costa, M. Fernanda Rodrigues, Laura C. Barreto, Maurício L. Gouveia, Mateus Horta, Bernardo L. Mambrini, Juliana Kehdy, Fernanda S. G. Pereira, Alexandre Rodrigues-Soares, Fernanda Victora, Cesar G. Tarazona-Santos, Eduardo Sci Rep Article Brazil never had segregation laws defining membership of an ethnoracial group. Thus, the composition of the Brazilian population is mixed, and its ethnoracial classification is complex. Previous studies showed conflicting results on the correlation between genome ancestry and ethnoracial classification in Brazilians. We used 370,539 Single Nucleotide Polymorphisms to quantify this correlation in 5,851 community-dwelling individuals in the South (Pelotas), Southeast (Bambui) and Northeast (Salvador) Brazil. European ancestry was predominant in Pelotas and Bambui (median = 85.3% and 83.8%, respectively). African ancestry was highest in Salvador (median = 50.5%). The strength of the association between the phenotype and median proportion of African ancestry varied largely across populations, with pseudo R(2) values of 0.50 in Pelotas, 0.22 in Bambui and 0.13 in Salvador. The continuous proportion of African genomic ancestry showed a significant S-shape positive association with self-reported Blacks in the three sites, and the reverse trend was found for self reported Whites, with most consistent classifications in the extremes of the high and low proportion of African ancestry. In self-classified Mixed individuals, the predicted probability of having African ancestry was bell-shaped. Our results support the view that ethnoracial self-classification is affected by both genome ancestry and non-biological factors. Nature Publishing Group 2015-04-27 /pmc/articles/PMC5386196/ /pubmed/25913126 http://dx.doi.org/10.1038/srep09812 Text en Copyright © 2015, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Lima-Costa, M. Fernanda Rodrigues, Laura C. Barreto, Maurício L. Gouveia, Mateus Horta, Bernardo L. Mambrini, Juliana Kehdy, Fernanda S. G. Pereira, Alexandre Rodrigues-Soares, Fernanda Victora, Cesar G. Tarazona-Santos, Eduardo Genomic ancestry and ethnoracial self-classification based on 5,871 community-dwelling Brazilians (The Epigen Initiative) |
title | Genomic ancestry and ethnoracial self-classification based on 5,871 community-dwelling Brazilians (The Epigen Initiative) |
title_full | Genomic ancestry and ethnoracial self-classification based on 5,871 community-dwelling Brazilians (The Epigen Initiative) |
title_fullStr | Genomic ancestry and ethnoracial self-classification based on 5,871 community-dwelling Brazilians (The Epigen Initiative) |
title_full_unstemmed | Genomic ancestry and ethnoracial self-classification based on 5,871 community-dwelling Brazilians (The Epigen Initiative) |
title_short | Genomic ancestry and ethnoracial self-classification based on 5,871 community-dwelling Brazilians (The Epigen Initiative) |
title_sort | genomic ancestry and ethnoracial self-classification based on 5,871 community-dwelling brazilians (the epigen initiative) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386196/ https://www.ncbi.nlm.nih.gov/pubmed/25913126 http://dx.doi.org/10.1038/srep09812 |
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