eNOS S-nitrosylates β-actin on Cys374 and regulates PKC-θ at the immune synapse by impairing actin binding to profilin-1

The actin cytoskeleton coordinates the organization of signaling microclusters at the immune synapse (IS); however, the mechanisms involved remain poorly understood. We show here that nitric oxide (NO) generated by endothelial nitric oxide synthase (eNOS) controls the coalescence of protein kinase C...

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Detalles Bibliográficos
Autores principales: García-Ortiz, Almudena, Martín-Cofreces, Noa B., Ibiza, Sales, Ortega, Ángel, Izquierdo-Álvarez, Alicia, Trullo, Antonio, Victor, Víctor M., Calvo, Enrique, Sot, Begoña, Martínez-Ruiz, Antonio, Vázquez, Jesús, Sánchez-Madrid, Francisco, Serrador, Juan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386235/
https://www.ncbi.nlm.nih.gov/pubmed/28394935
http://dx.doi.org/10.1371/journal.pbio.2000653

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